With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90533-23-6,4-(3-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.,90533-23-6
Step 3:; To a solution of 4-(3-chlorophenyl)thiazol-2-amine (1 g) in tetrahydrofuran (20 mL) was added NBS (0.88 g). After stirring at room temperature overnight, the mixture was partitioned between ethyl acetate (30 mL) and water (20 mL). The organic phase was washed with water (20 mL x 2), dried and concentrated to give 5-bromo-4-(3-chlorophenyl)thiazol-2-amine (1.05 g) as a red liquid. MS(ES ) m/z 289 (MH ).
90533-23-6 4-(3-Chlorophenyl)thiazol-2-amine 675261, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting; WO2012/100734; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica