With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: Ethyl benzothiazole-2-carboxylate 4a (1 mmol) was taken in around bottom flask (10 mL). To it the aliphatic amine (4 equiv.) wasadded in excess along with (50 mg) of NH4Cl. The reaction mixturewas heated at 150 C for 2e3 h under magnetic stirring. Aftercompletion of reaction (TLC), the mixture was diluted using EtOAc,washed with1N HCl and brine, dried over anhydrous MgSO4 andconcentrated under reduced pressure to furnish the final productthat was then washed with cooled hexane.
32137-76-1, The synthetic route of 32137-76-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ghonim, Aya E.; Ligresti, Alessia; Rabbito, Alessandro; Mahmoud, Ali Mokhtar; Di Marzo, Vincenzo; Osman, Noha A.; Abadi, Ashraf H.; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 154 – 170;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica