6633-61-0,6633-61-0, Methyl 2-aminothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE I Preparation of Methyl 2-chlorothiazole-5-carboxylate To 5.0 g of methyl 2-aminothiazole-5-carboxylate [H. E. Faith, U.S. Pat. No. 2,405,820(1946)] suspended in 54 ml of 6 N hydrochloric acid stirred at-5-0 was added dropwise over 15 minutes 3.7 g of sodium nitrite dissolved in 10 ml of water. After stirring 5 minutes, the brown suspension was added in one portion to a rapidly stirred suspension of 10.6 g of cupric sulfate and 10.6 g of sodium chloride cooled at 5. The cooling bath was removed and stirring was continued for 30 minutes. The pH was adjusted to 7.3 with 6 N sodium hydroxide and the green suspension was filtered through Celite. The solid was washed with three portions of ethyl acetate and the extract was combined with the ethyl acetate extract of the original filtrate. After drying the combined extract over magnesium sulfate, concentration in vacuo gave a brown solid. Trituration with four portions of hot petroleum ether (35-60) served to separate the soluble product from some starting material. Concentration in vacuo of the petroleum ether solution gave 3.9 g. of pure methyl 2-chlorothiazole-5-carboxylate having a melting point of 41-46.
The synthetic route of 6633-61-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hoffmann-La Roche Inc.; US4168380; (1979); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica