Day: November 10, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.

2- (3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) imidazo [1,2- a] pyridine(100 mg, 0.31 mmol),Palladium acetate (4 mg, 0.016 mmol),Triphenylphosphine (16 mg, 0.06 mmol),And sodium carbonate (66 mg, 0.62 mmol)After adding 1,4-dioxane and water at a ratio of 1: 1 in 2 mL portions4-Bromothiazole (51 mg, 0.31 mmol) was added thereto, and the mixture was stirred at 90 ¡ã C for 16 hours.After the reaction is completed, the reaction mixture is cooled to room temperature and the reaction product is separated into water and ethyl acetate. The combined organic layers were concentrated and the concentrate was purified by silica gel column chromatography (dichloromethane: ethyl acetate, 10: 1 v / v) to give 4- (3- (imidazo [1,2- a] pyridin- ) Phenyl) thiazole (45 mg, 52percent).

34259-99-9, As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Jeon Mun-guk; Kim Gwang-rok; Huh Yun-jeong; Lee Jun-mi; (27 pag.)KR2018/101671; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

29927-08-0, 5,6-Dimethylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Preparation of acetoacetamide derivatives (3a-e) was carried out as shown in Scheme 1. 2,2,6-Trimethyl-1,3- dioxine-4-one (1) (2eq) and appropriate arylamine (2a-e) (1eq) were mixed and refluxed for about 2-4h in toluene. The progress of the reactions was checked by TLC. Upon completion of the reaction, the product was filtered, washed with small portions of petroleum ether. Further purification was performed by crystallization of obtained product in hot ethanol. Characteristics data for prepared N-(aryl)-3- oxobutanamides are as follows:

29927-08-0, The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ebadi, Ahmad; Khoshneviszadeh, Mehdi; Javidnia, Katayoun; Ghahremani, Mohammad Hossein; Firuzi, Omidreza; Miri, Ramin; Letters in drug design and discovery; vol. 14; 8; (2017); p. 885 – 897;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

88982-82-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 4-bromothiazole-2-carboxylic acid 8 (5.5 g, 26.8 mmol) in anhydrous DMF (30 mL) was added carbonyl diimidazole (CDI) (5.2 g, 32.3 mmol), and the reaction mixture was stirred at room temperature for 1 h. (E)-4-[3-(3,4,5-Trimethoxyphenyl]-1,2,4-thiadiazol-5-ylamino)-N’-hydroxybenzamidine 7 (13 g, 32.3 mmol) was added to the reaction mixture and it was stirred at 110 C for 15 h. After completion of the process, the mixture was cooled down and poured into ice-cold water (35 mL), extracted by ethyl acetate (3¡Á15 mL), and the combined organic phases were washed with brine, dried over anhydrous sodium sulphate, filtered off, and concentrated under vacuum. The crude product was purified by column chromatography using ethyl acetate/hexane (1 : 1) to afford pure compound 9, yield 79 %.

The synthetic route of 88982-82-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sudhakar; Rao, A. Srinivasa; Reddy, Ch. Venkata Ramana; Russian Journal of General Chemistry; vol. 89; 8; (2019); p. 1696 – 1701;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

78364-55-3, General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

The synthetic route of 78364-55-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

556-90-1, General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.3 5-(4-Hydroxy-3-methoxybenzylidene)-2-iminothiazolidin-4-one (14c) Yellow solid; mp > 200 C; 215 mg, 43% yield; IR (neat) numax = 3364, 2955, 1735, 1680, 1584 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.76 (s, 1H), 9.29 (br s, 1H), 9.05 (s, 1H), 7.50 (s, 1H), 7.13 (s, 1H), 7.06 (d, J = 8.28, 1H), 6.9 (d, J = 7.92, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 175.91, 148.92, 148.35, 130.35, 125.94, 125.81, 123.69, 116.49, 113.88, 56.00; HRMS (ESI-TOF): m/z calculated for C11H10N2O3S [M+H]+, 251.0490; found 251.0491.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

383865-57-4, 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyl-3-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-urea Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and benzylamine the title compound was obtained as an off-white solid (99%), MS: m/e=399 (M+H+).

383865-57-4, 383865-57-4 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine 11402861, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of 1,2-benzisothiazol-3-one 1 (151 mg, 1 mmol), inTHF (10 ml), K2CO3 (276 mg, 2 mmol) was added at room temperaturefor 30 min, then t-butyl bromoacetate 10 (195 mg, 1 mmol)was added. After the reaction was stirred at room temperaturefor 3 h, the solvent was removed under vacuum. The residualwas isolated by column chromatography (ethyl acetate/petroleumether, 15:1) to yield 11. The intermediate 11 (265 mg, 1 mmol) indry CH2Cl2 (10 ml) was treated with trifluoroacetic acid (TFA,3.3 ml) for 5 h at room temperature and the solvent was removedunder vacuum. The residue washed with ethyl ether (2 25 ml) toyield the desired product 12 as white solid. A solution of compound 12 (209 mg, 1 mmol) in dry THF(10 ml) was added portion wise to a suspension of carbonyldiimidazole(162 mg, 1 mmol) in THF (5 ml) and the mixture was stirredat room temperature for 20 min and then refluxed for 10 min.A solution of primary amine (1 mmol) in THF (5 ml) was addedand the reaction mixture was stirred at room temperature overnight.A white precipitate formed, which was collected by suctionfiltration.

2634-33-5, The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Lixin; Lu, Meiqi; Yan, Zhihui; Tang, Xiaobin; Sun, Bo; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 8; (2014); p. 2416 – 2426;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7504-44-1,7504-44-1, 2-(4-Thiazolyl)acetic Acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

HATU (2.12 g, 5.58 mmol) was added to a mixture containing of 2-((lr, 4r)-4-((5 -amino-i -(phenyl sulfonyl)- 1H-pyrrolo[2,3 -b]pyridin-4- yl)amino)cyclohexyl)acetonitrile (Intermediate 2, 1.14 g, 2.78 mmol), 2-(thiazol-4-yl)acetic acid(400 mg, 2.79 mmol), DIPEA (722 mg, 5.59 mmol)and DMF (10 mL) at 0 C (ice / water) and was stirred at room-temperature for 2 hours. The reaction was partitioned between EtOAc (100 mL) and water (100 mL), the aqueous phase was extracted with ethyl acetate (50 mL x 3) and the combined organic extracts were dried over anhydrous Na2504, filtered, and concentrated to dryness. The residue was purified by flash column chromatography to provide the titlecompound (1.5 g, 95% yield) as a yellow solid. MS (ESI): mass calcd. for C26H26N60352,534.65; m/z found, 534.9 [M+H]t

7504-44-1 2-(4-Thiazolyl)acetic Acid 236262, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BACANI, Genesis M.; CHAI, Wenying; KOUDRIAKOVA, Tatiana; KRAWCZUK, Paul J.; KREUTTER, Kevin D.; LEONARD, Kristi; RIZZOLIO, Michele C.; SEIERSTAD, Mark; SMITH, Russel C.; TICHENOR, Mark S.; VENABLE, Jennifer D.; WANG, Aihua; (452 pag.)WO2018/112382; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

69812-29-9, General procedure: To a solution of 1 (0.5g, 2mmol) in CH2Cl2 (30mL), K2CO3 (1.8g, 6mmol) and the substituted benzoyl chloride (2mmol) were added and stirred at 0C untill the TLC analysis showed completion of the reaction, then filterd. The filtrate was washed with water, brine, dried, filtered and concentrated. Then the residue was purified by flash column chromatography on silica gel with CH2Cl2/CH3OH as the eluent to give the title compounds.

69812-29-9 2-Acetamido-4-methylthiazole-5-sulfonyl chloride 96951, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Xin; Lv, Xiao-Qin; Tang, Sheng; Mei, Lin; Li, Ying-Hong; Zhang, JingPu; Jiang, Jian-Dong; Peng, Zong-Gen; Song, Dan-Qing; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1053 – 1065;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

777-12-8, 6-(Trifluoromethyl)benzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

777-12-8, To a stirred solution of methyl 5-chloro-3-cyano-2-methoxybenzoate (86mg, 0.382mmo1) in MeOH (3m1) was added 2.0 ml iN KOH solution. The resulting mixture was stirred at 60¡ãC overnight. The solvent was evaporated out and 4N HC1 in dioxane (lml) was added to the residue. The mixture was stirred for another 10mm before it was concentrated and dried under vacumn. To this residue was added HBTU (172mg, 0.456mmo1), DMF (3m1) and DIPEA (330u1, 1.9 mmol). The mixture was stirred for lOmins and then 6-(trifluoromethyl)benzo[d]thiazol-2-amine (83mg, 0.3 8mmol) was added. The resulting reaction was heated at 120 ¡ãC for 24hs. After cooled to rt, the mixture was separated between EA and water. The organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by column chromatography gave the 5-chloro-3-cyano-2- hydroxy-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)b enzamide as a yellow solid (62mg, 42percent). ?H NMR (300 IVIHz, Acetone-d6) 8.31 (dt, J = 1.6, 0.9 Hz, 1H), 7.85 (d, J = 3.0 Hz, 1H), 7.79 -7.65 (m, 2H), 7.14 (d, J = 3.0 Hz, 1H). MS (ESI) [M+H] requires m/z 398.00, found m/z 397.95.

The synthetic route of 777-12-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JIN, Shengkan; AUGERI, David J.; CAO, Bin; TAO, Hanlin; (126 pag.)WO2017/201313; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica