With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.
2- (3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) imidazo [1,2- a] pyridine(100 mg, 0.31 mmol),Palladium acetate (4 mg, 0.016 mmol),Triphenylphosphine (16 mg, 0.06 mmol),And sodium carbonate (66 mg, 0.62 mmol)After adding 1,4-dioxane and water at a ratio of 1: 1 in 2 mL portions4-Bromothiazole (51 mg, 0.31 mmol) was added thereto, and the mixture was stirred at 90 ¡ã C for 16 hours.After the reaction is completed, the reaction mixture is cooled to room temperature and the reaction product is separated into water and ethyl acetate. The combined organic layers were concentrated and the concentrate was purified by silica gel column chromatography (dichloromethane: ethyl acetate, 10: 1 v / v) to give 4- (3- (imidazo [1,2- a] pyridin- ) Phenyl) thiazole (45 mg, 52percent).
34259-99-9, As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.
Reference£º
Patent; Korea Research Institute of Chemical Technology; Jeon Mun-guk; Kim Gwang-rok; Huh Yun-jeong; Lee Jun-mi; (27 pag.)KR2018/101671; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica