88982-82-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of 4-bromothiazole-2-carboxylic acid 8 (5.5 g, 26.8 mmol) in anhydrous DMF (30 mL) was added carbonyl diimidazole (CDI) (5.2 g, 32.3 mmol), and the reaction mixture was stirred at room temperature for 1 h. (E)-4-[3-(3,4,5-Trimethoxyphenyl]-1,2,4-thiadiazol-5-ylamino)-N’-hydroxybenzamidine 7 (13 g, 32.3 mmol) was added to the reaction mixture and it was stirred at 110 C for 15 h. After completion of the process, the mixture was cooled down and poured into ice-cold water (35 mL), extracted by ethyl acetate (3¡Á15 mL), and the combined organic phases were washed with brine, dried over anhydrous sodium sulphate, filtered off, and concentrated under vacuum. The crude product was purified by column chromatography using ethyl acetate/hexane (1 : 1) to afford pure compound 9, yield 79 %.
The synthetic route of 88982-82-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Sudhakar; Rao, A. Srinivasa; Reddy, Ch. Venkata Ramana; Russian Journal of General Chemistry; vol. 89; 8; (2019); p. 1696 – 1701;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica