Day: November 12, 2020

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.4 5-(4-Hydroxy-3-nitrobenzylidene)-2-iminothiazolidin-4-one (14d) Orange solid; mp > 200 C; 330 mg, 61% yield; IR (neat) numax = 3164, 2772, 1679, 1604 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.46 (br s, 1H), 9.18 (s, 1H), 8.05 (s, 1H), 7.75 (d, J = 8.74, 1H), 7.55 (s, 1H), 7.24 (d, J = 8.72, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 180.71, 175.57, 153.52, 137.52, 136.46, 129.04, 127.52, 126.27, 125.66, 120.53 HRMS (ESI-TOF): m/z calculated for C10H7N3O4S [M+Na]+, 288.0055; found 288.0046.

As the paragraph descriping shows that 556-90-1 is playing an increasingly important role.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-79-9,2-Amino-4-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

5464-79-9, Step A. A solution of AICl3 (5 mmole) in ETSH (10 ML) was cooled to 0 C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole).. The mixture was stirred at 0-5 C. for 2 h.. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

5464-79-9 2-Amino-4-methoxybenzothiazole 21622, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Metabasis Therapeutics, Inc.; US6756360; (2004); B1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56012-38-5,(2-Methylthiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

To a stirred solution of compound 64 (5 g, 38.75 mmol) in CH2C12 (150 mL) under inert atmosphere were added triethyl amine (8.3 mL, 58.13 mmol), methanesulfonyl chloride (4.6 mL, 46.51 mmol) at 0 C; warmed to RT and stirred for 4 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was diluted with water (50 mL) andextracted with CH2C12 (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford compound 65 (5 g, 87%) as a pale-yellow syrup. TLC: 30% EtOAc/ hexanes (Rf: 0.8); LC-MS: 77.92%; 147.7 (M+1) (column; Ascentis Express C18, (50 x 3.0 mm, 2.7 jim); RT 1.71 mm. 0.025% Aq. TFA + 5% ACN: ACN + 5% 0.025% Aq. TFA, 1.2 mL/min).

56012-38-5, 56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASSEMBLY BIOSCIENCES, INC.; TURNER, William; ARNOLD, Lee, Daniel; LI, Leping; BURES, Mark; HAYDAR, Simon; MAAG, Hans; BANNEN, Lynne; (176 pag.)WO2018/53157; (2018); A1;,
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Thiazole | chemical compound | Britannica

19952-47-7, 2-Amino-4-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: A mixture of 2-aminobenzothiazole (0.150g, 1mmol), phenyl isothiocyanate (0.135g, 1 mmol) and Dimethyl amino pyridine (5 mol%) in DMF (1 mL) was stirred at room temperature for 2.0 h and the progress of the reaction was followed by TLC. After completion of the reaction, water (5 mL) was added to reaction mixture and extracted with ethyl acetate (2×5 mL). The organic layer was separated and dried over anhy. Na2SO4, and solvent was removed under reduced pressure. The crude product was purified by column chromatography (60-120 mesh) using (ethyl acetate: n-hexane, 10:90) to obtain 3a (0.256g, 90%) as a white powder.

19952-47-7, As the paragraph descriping shows that 19952-47-7 is playing an increasingly important role.

Reference£º
Article; Kumbhare, Ravindra M.; Dadmal, Tulshiram; Kosurkar, Umesh; Sridhar; Rao, J. Venkateswara; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 453 – 455;,
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Thiazole | chemical compound | Britannica

7305-71-7, 2-Amino-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Comparative Example 1 Synthesis of 2-chloro-5-methylthiazole In a 300 ml volume three necked flask equipped with a stirrer, a dropping funnel and a thermometer, 20 g of 2-amino5-methylthiazole (0.175 mol), 35 ml of 36% hydrochloric acid (0.407 mol) and 30 ml of water were placed and cooled to -5 C. To the mixture, 14 g of sodium nitrite (0.203 mol) dissolved in 30 ml of water was gradually added dropwise at 0 C. or lower. The reaction mixture was further caused to react for three hours at 0 C. or lower to give the diazonium base. The reaction mixture was heated to 80 C. for three hours and extracted with three 40 ml portions of chloroform to give a chloroform solution containing 2-chloro-5-methylthiazole. The chloroform was removed by atmospheric distillation and remained fraction was distilled under reduced pressure to isolate 10.3 g of 2-chloro-5-methylthiazole (0.077 mol) with a yield of 44%., 7305-71-7

Big data shows that 7305-71-7 is playing an increasingly important role.

Reference£º
Patent; Kureha Chemical Industry Co., Ltd.; US5811555; (1998); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

0.15 mmol6-(2-chloropyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole,0.30 mmol 4-cyclopropyl-2-aminothiazole,0.025 mmol of tris(dibenzylideneacetone) dipalladium,0.028 mmol 2-dicyclohexylphosphor-2′,6′-diisopropoxy-1,1′-biphenyl,Mix 0.5 mmol cesium carbonate and 80 mL 1,4-dioxane.Put it on a vacuum pump for 10 minutes.Remove the water in the reaction material,In an argon atmosphere,110 ¡ãC reaction overnight;After the reaction is completed, naturally cool to room temperature.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.Dry the resulting organic layer under reduced pressureThen column chromatography,N-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)pyrimidin-2-amine is obtained;0.5mmolN-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)Pyrimidin-2-amine,Mix 5 mL of ethanol with 0.5mL of hydrochloric acid 1,4-dioxane solution.70 ¡ã C reaction 2h;After the reaction is complete, the resulting material is adjusted to pH 8 with saturated sodium bicarbonate solution.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.The resulting organic layer was spin-dryed under reduced pressure and then subjected to column chromatography.The target product N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine was obtained as a white solid.(N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine.Compound No. 2n)., 324579-90-0

As the paragraph descriping shows that 324579-90-0 is playing an increasingly important role.

Reference£º
Patent; South Medical University Zhongxiyi Binding Hospital; Zhu Zhibo; Zhou Jin; Yang Zike; Wang Hao; Liao Bohong; (21 pag.)CN107721991; (2018); A;,
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Thiazole | chemical compound | Britannica

14527-41-4, 5-Thiazolecarboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 3: Step a N-Methoxy-N-methylthiazole-5-carboxamide Triethylamine (2.77 mL, 19.9 mmol) was added slowly to a mixture of commercially available thiazole-5-carboxylic acid (1.03 g, 7.98 mmol), N,O-dimethylhydroxylamine hydrochloride (0.778 g, 7.98 mmol), and EDCI (1.83 g, 9.57 mmol) in CH2Cl2 (10 mL). The mixture was stirred at room temperature for 72 hours then quenched with saturated aqueous NaHCO3. Water (50 mL) was added followed by additional CH2Cl2. The mixture was stirred for 10 minutes and layers were separated. The CH2Cl2 layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure and the residual oil was chromatographed (CH2Cl2/EtOAc) to provide the title compound as a white solid., 14527-41-4

14527-41-4 5-Thiazolecarboxylic acid 84494, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; LEONARD, KRISTI A.; BARBAY, KENT; EDWARDS, JAMES P.; KREUTTER, KEVIN D.; KUMMER, DAVID A.; MAHAROOF, UMAR; NISHIMURA, RACHEL; URBANSKI, MAUD; VENKATESAN, HARIHARAN; WANG, AIHUA; WOLIN, RONALD L.; WOODS, CRAIG R.; FOURIE, ANNE; XUE, XIAOHUA; US2014/107096; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693-95-8,4-Methylthiazole,as a common compound, the synthetic route is as follows.

-Hydroxy-4-(4-methylthiazol-5-yl)benzonitrile Under an atmosphere of nitrogen, a mixture of 4-bromo-2-hydroxybenzonitrile (commercially available from for example Fluorochem) (15 g, 76 mmol), 4-methylthiazole (commercially available from for example Aldri

693-95-8, 693-95-8 4-Methylthiazole 12748, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; YALE UNIVERSITY; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CAMBRIDGE ENTERPRISE LIMITED UNIVERSITY OF CAMBRIDGE; CREWS, Craig, M.; BUCKLEY, Dennis; CIULLI, Alessio; JORGENSEN, William; GAREISS, Peter, C.; MOLLE, Inge, Van; GUSTAFSON, Jeffrey; TAE, Hyun-Seop; MICHEL, Julien; HOYER, Dentin, Wade; ROTH, Anke, G.; HARLING, John, David; SMITH, Ian Edward, David; MIAH, Afjal, Hussain; CAMPOS, Sebastian, Andre; LE, Joelle; WO2013/106646; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

4-Oxo-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and piperidin-4-one the title compound was obtained as white solid (38%). MS: m/e=391 (M+H+).

383865-57-4, As the paragraph descriping shows that 383865-57-4 is playing an increasingly important role.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica