Day: November 13, 2020

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of cyclohexyl-2-(phenylimino)-4-thiazolidineione,3-methyl-2-(phenylimino) thiazolidine-4-one, thiazolidine-2,4-dione, 3-methyl thiazolidine-2,4-dione or imidazolidine-2,4-dione (1.0 equiv) in absolute ethanol (15 mL) was added theappropriate 2,5-dimethyl-1-aryl -3-formylpyrrole (1.1 equiv),piperidine (1.2 equiv) and 3 molecular sieves. The mixture washeated to reflux at 90 C for 8e10 h, cooled, filtered and concentratedin vacuo. The residue was purified by column chromatographyon a silica gel column (ethylacetate/hexane ordichloromethane/hexane) and in some cases recrystallized frommethanol to give 20e54 as generally yellowish solids.

556-90-1, 556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Mital, Alka; Murugesan, Dinakaran; Kaiser, Marcel; Yeates, Clive; Gilbert, Ian H.; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 530 – 538;,
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Thiazole | chemical compound | Britannica

1123-99-5, 2-Iodobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under a nitrogen atmosphere, in 25 ml substrate is added into the test tube reactor 3dfm (0.2mmol, 52.0 mg), 1-chloro-butane (3.0mmol, 276.0 mg), PdCl2(dppf) (0.02mmol, 14.6 mg), DPPF (0.01mmol, 5.6 mg), Cs2CO3(0.3mmol, 195.0 mg), Na2S2O35H2O (0.5mmol, 248.0 mg), DMSO (4.0 ml) and glycol (0.1 ml). Heating the reaction system to 120 C for reaction. TLC detection after the reaction is ended, the system is cooled to room temperature. Hydrosolvent quenching reaction with saturated ammonium chloride, extracted with ethyl acetate (3*10 ml), column chromatography purification to obtain the product 3df (62%)., 1123-99-5

1123-99-5 2-Iodobenzo[d]thiazole 827981, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; East China Normal University; JIANG, XUE FENG; QIAO, ZONG JUN; (33 pag.)CN103848767; (2016); B;,
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Thiazole | chemical compound | Britannica

24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ketone (20 mmol) (2-acetylpyridine, 2-acetylthiazole or 2-acetylpyrazine)was added to a solution of aldehyde (10 mmol) (4-methoxybenzaldehyde,4-methoxy-1-naphthaldehyde or 6-methoxy-2-naphthaldehyde) in EtOH (75 mL). KOH (1.54 g, 27.5 mmol) and NH3(aq)(35 mL) were then added. The solution was stirred at room temp. for 24 h. The solid was collected by filtration and washed with H2O. Recrystallization from ethanol (L1,L4, L7) or toluene (L2, L3, L5, L6, L8,L9) afforded a crystalline solid.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.911466-96-1,2-(Ethoxycarbonyl)thiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Isobutyl chloroformate (1.16 ml, 8.95 mmol) was added to an ice-cooled (0C) suspension of 2- (ethoxycarbonyl)-1 ,3-thiazole-4-carboxylic acid (216) (1.5 g, 7.46 mmol) and TEA (1 .25 ml, 8.95 mmol) in THF (60 ml). The reaction was stirred at 0C for 1 h. The reaction was filtered through a plug of Celite and NaBH4 (0.705 g, 18.64 mmol) was added to the filtrate and stirred for 2h. The reaction was diluted with sat. aq. Na2C03 solution and stirred for 10 mins, then extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2S04), filtered and the solvent evaporated. Purification by flash column chromatography (eluting with a gradient of 40-50% EtOAc-Heptane) gave the titled compound (0.734 g, 52.6%) as a crystalline solid. 1 H-NMR (DMSO-d6, 500 MHz) d[ppm]= 7.85 (s, 1 H), 5.50 (t, J = 5.8 Hz, 1 H), 4.63 (dd, J = 5.8, 0.8 Hz, 2H), 4.37 (q, J = 7.1 Hz, 2H), 1.33 (d, J = 7.1 Hz, 3H) HPLCMS (ESI+): [m/z]: 187.90 [M+H], 911466-96-1

911466-96-1 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid 53487863, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; VIFOR (INTERNATIONAL) AG; DUeRRENBERGER, Franz; BUHR, Wilm; BURCKHARDT, Susanna; BURGERT, Michael; KALOGERAKIS, Aris; REIM, Stefan; MANOLOVA, Vania; BOYCE, Susan; YARNOLD, Christopher John; PENA, Paula; SHEPHERD, Jon; LECCI, Cristina; JARJES-PIKE, Richard; SCOTT, John; (416 pag.)WO2017/68089; (2017); A2;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.117724-63-7,2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.,117724-63-7

9-Dichloromethylidene-5-amino-benzonorbomene (175 mg, 0.73 mmol), 2- methyl-4-trifluoromethyl-thiazole-5-carboxylic acid (162 mg, 0.77 mmol, 1.05 eq.) and triethylamine (184 mg, 1.8 mmol, 2.5 eq.) were reacted with bis-(2-oxo-3-oxazolidinyl)- phosphinic acid chloride (278 mg, 1.09 mmol, 1.5 eq.) in dichloromethane (10 ml) at 25 0C for 20 hours. The reaction mixture in ethyl acetate was washed successively with water and saturated. Sodium chloride solution, dried over sodium sulphate, evaporated and purified on silica gel (ethyl acetate-hexane-(l:2) to give 250 mg colourless crystals (m.p. 136-139 0C).

The synthetic route of 117724-63-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; WO2007/48556; (2007); A1;,
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Thiazole | chemical compound | Britannica

668484-45-5, 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

668484-45-5, 2-(4-(tert-butoxycarbonyl)piperazin- 1 -yl)thiazole4-carboxylic acid (156 mg, 0.5 mmol), tert-butyl 2-amino-4-(thiophen-2-yl) phenylcarbamate (130 mg, 0.45 mmol) and EDCI (191 mg, 1 mmol) were added into Py (5 ml). The mixture was stirred at room temperature for overnight. When the reaction finished, it was concentrated and water was added. The yellow solid was collected as product (210 mg, 80% yield).

As the paragraph descriping shows that 668484-45-5 is playing an increasingly important role.

Reference£º
Patent; Regenacy Pharmaceuticals, LLC; van Duzer, John H.; Mazitschek, Ralph; (123 pag.)US2018/141923; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.21 2-(3-(4-Methoxyphenyl)propanoyl)benzo[d]isothiazol-3(2H)-one (25) Compound 25 was prepared through 3-(4-methoxyphenyl)propionic acid, obtained a white solid in 94% yield. Mp 110.8-112.1 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 8.0 Hz, 1H), 7.20 (d, J = 8.4 Hz, 2H), 6.86 (d, J = 8.4 Hz, 2H), 3.72 (s, 3H), 3.36 (t, J = 7.6 Hz, 2H), 2.90 (t, J = 7.6 Hz, 2H). 13C NMR (101 MHz, DMSO-d6) delta 172.7, 163.5, 158.1, 141.3, 135.0, 132.9, 129.8, 127.4, 126.6, 125.7, 122.5, 114.2, 55.4, 39.4, 29.2. IR (KBr, cm-1): 1690, 1671. HRMS-ESI (m/z) calcd for C17H15NO3S [M+H+] 314.0851, found 314.0836.

2634-33-5, As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-77-3,2,4-Dibromothiazole,as a common compound, the synthetic route is as follows.

Frame-dried 200 mL four-necked flask was purged with nitrogen and Xantphos (Xantphos, 220 mg, 0.38 mmol),Tris (dibenzylideneacetone) dipalladium (0) (Pd 2 (dba) 3,840 mg, 0.38 mmol) and dry tetrahydrofuran (dry THF, 75 mL) were added and stirred for 5 minutes, Thereby preparing a THF solution.Another flame-dried 200 mL four-necked flask was purged with nitrogen, 2,4-dibromothiazole (Compound 101 in the following formula (A), 3.6 g, 15 mmol),Phenylboronic acid (1.9 g, 16 mmol),Triopotassium phosphate (9.6 g, 45 mmol),The above THF solution was added, And the mixture was heated under reflux at 60 C. for 18 hours.After returning to room temperature,Celite filtration was carried out using dichloromethane. Removal of the solvent and purification by column chromatography gave the compound of the following formula (A), And 2.4 g of a white solid compound represented by “102” (yield: 66%).

4175-77-3, As the paragraph descriping shows that 4175-77-3 is playing an increasingly important role.

Reference£º
Patent; Nara Institute of Science and Technology; Kawai, Tsuyoshi; Asato, Ryousuke; Yanagida, Takayuki; Okada, Go; Nakajima, Takuya; (35 pag.)JP2018/140974; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.121-66-4,5-Nitrothiazol-2-amine,as a common compound, the synthetic route is as follows.

N- (5-Nitro-1, 3-thiazol-2-yl) pentanamide To a solution of 2-amino-5-nitrothiazole (205 mg, 1.41 mmol) and triethylamine (271 muL, 2.11 mmol) in methylene chloride (25 mL) was added dropwise n-valeroylchloride (180 pL, 1.48 mmol). The reaction solution was stirred over night and washed with a saturated sodium bicarbonate solution. The layers were separated and the organic layer was dried with sodium sulfate, filtered and concentrated. The crude product was purified on a silica gel column using hexane/ethyl acetate (4: 1) as the eluent to give 130 mg (40% yield) of the title compound as a light yellow solid: mp 155-156 C ; IH NMR (CDC13, 300 MHz) 8 11.2 (br s, 1 H), 8.29 (s, 1 H), 2. 59 (t, J= 7 Hz, 2 H), 1.84-1. 74 (m, 2 H), 1. 51-1. 39 (m, 2 H), 0. 98 (t, J= 7 Hz, 3 H) ; 13C NMR (CDC13, 75 MHz) 8 171. 67,162. 02,143. 46, 139. 46, 35.98, 26.38, 22.24, 13.67 ; EIMS (70 eV) m/z (relative intensity) 229 (M+, 34), 85 (100), 57 (24)., 121-66-4

121-66-4 5-Nitrothiazol-2-amine 8486, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2003/89419; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 334: Methyl 2-(3-(4-(6-fluorobenzo[d]thiazol-2-yloxy)phenyl)isoxazole-5- carboxamido)-3-methylbutanoate; To methyl 2-(3-(4-hydroxyphenyl)isoxazole-5-carboxamido)-3-methylbutanoate (200 mg) in N,N’ -Dimethyl formamide (4 ml), cesium carbonate (245 mg) was added and stirred for 15 -20 minutes. To this 2-chloro-6-fluorobenzo[d]thiazole (141 mg) was added and the reaction mixture was stirred at RT for 18 hours. Solvent was evaporated to obtain pale brown solid, which was purified by column chromatography (silica gel, EtOAc – CHCI3) to obtain off white solid, which was crystallized using DCM- Petroleum ether to obtain the title compound as white solid. Yield: 240 mg (81 %); MS (ES+): m/z 470 (M+l); 1HNMR (DMSOd6,300MHz): delta 9.27 (d, IH), 8.08 (d, 2H), 7.93 (dd, IH), 7.8 (s, IH), 7.74 (dd, IH), 7.67 (d, 2H),7.31 (m, IH), 4.33 (m, IH), 3.69 (s, 3H), 2.23 (m, IH), 0.98 (d, 6H)., 399-74-6

The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMAL LIFE SCIENCES LIMITED; GANGOPADHYAY, Ashok Kumar; KADAM, Kishorkumar, Shivajirao; JADHAV, Ravindra, Dnyandev; MISTRY, Hitesh; SHARMA, Rajiv; WO2010/23609; (2010); A1;,
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Thiazole | chemical compound | Britannica