Analyzing the synthesis route of 556-90-1

556-90-1, 556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of cyclohexyl-2-(phenylimino)-4-thiazolidineione,3-methyl-2-(phenylimino) thiazolidine-4-one, thiazolidine-2,4-dione, 3-methyl thiazolidine-2,4-dione or imidazolidine-2,4-dione (1.0 equiv) in absolute ethanol (15 mL) was added theappropriate 2,5-dimethyl-1-aryl -3-formylpyrrole (1.1 equiv),piperidine (1.2 equiv) and 3 molecular sieves. The mixture washeated to reflux at 90 C for 8e10 h, cooled, filtered and concentratedin vacuo. The residue was purified by column chromatographyon a silica gel column (ethylacetate/hexane ordichloromethane/hexane) and in some cases recrystallized frommethanol to give 20e54 as generally yellowish solids.

556-90-1, 556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Mital, Alka; Murugesan, Dinakaran; Kaiser, Marcel; Yeates, Clive; Gilbert, Ian H.; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 530 – 538;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica