Day: November 16, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693-95-8,4-Methylthiazole,as a common compound, the synthetic route is as follows.,693-95-8

General procedure: Aniline ligand (10.0mmol) and palladium dichloride (0.886g, 5.0mmol) were dissolved in 15mL of DMAc at room temperature. After the mixture was stirred for 0.5hat 80C, the methanol (50mL) was added and the precipitation was formed. The precipitate of palladium complexes was then dissolved in 5mL dichloromethane, then 20mL hexane was added. After crystallized from the mixture of ethanol and dichloromethylene, the palladium complex was obtained as light yellow crystals.

As the paragraph descriping shows that 693-95-8 is playing an increasingly important role.

Reference£º
Article; He, Xiao-Xi; Li, Yan-Fang; Huang, Ju; Shen, Dong-Sheng; Liu, Feng-Shou; Journal of Organometallic Chemistry; vol. 803; (2016); p. 58 – 66;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-40-3,6-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

6-Fluoro-2-hydrazinobenzothiazole (2). Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

348-40-3, The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

6436-59-5, Production Example 49; To a solution of ethyl 2-methyl-1,3-thiazole-4-carboxylate (14.53 g) in MeCN (150 mL) was added NBS (22.66 g), followed by heating under reflux for 3 hours. To the reaction mixture was added NBS (7.55 g), followed by heating under reflux for 2 hours. Under ice-cooling, to the reaction mixture was added a saturated aqueous NaHCO3 solution, followed by stirring for 5 minutes, and then extraction with EtOAc. The organic layer was dried over MgSO4 and then concentrated under reduced pressure. The residue obtained was purified by silica gel column chromatography (hexane:EtOAc = from 100:0 to 60:40) to obtain ethyl 5-bromo-2-methyl-1,3-thiazole-4-carboxylate (8.52 g) as a yellow solid.

As the paragraph descriping shows that 6436-59-5 is playing an increasingly important role.

Reference£º
Patent; Astellas Pharma Inc.; EP2119716; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2786-51-8,5-Chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

2786-51-8, General procedure: 1 mL Xylene was added into the flask charged with 0.25 mmol 4-quinolinonyl triflate, 0.75 mmol benzothiazole, 5 mol% Pd(TFA)2 (4.1 mg), 20 mol% PCy (14 mg), 0.25 mmol K2CO3, 10 mol% CuI (4.7 mg). The mixture was stirred at 140oC under Ar for 12 hours, then cooled down to room temperature, diluted with 20 mL ethyl acetate and washed with 10 mL H2O. The aqueous layer was extracted twice with ethyl acetate (5 mL) and the combined organic phase was dried over Na2SO4. After evaporation of the solvents the residue was purified by flash column chromatography (silica gel, PE/EtOAc) to afford the desired products 3 and 5.

2786-51-8 5-Chlorobenzo[d]thiazole 14388566, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Guo, Tao; Tetrahedron Letters; vol. 57; 51; (2016); p. 5837 – 5840;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63139-97-9,(2-Methylthiazol-5-yl)methanamine,as a common compound, the synthetic route is as follows.

63139-97-9, To the solution of 4-bromo-2-methyl-6-(((1S,2S)-2-(1-methyl-1H-pyrazol-3-yl)cyclopropyl)methoxy)pyridazin-3(2H)-one (made according to Example 1, by replacing ((1S,2S)-2-( 5-methylpyridin-2-yl)cyclopropyl)methanol with ((I S,2S)-2-(1-methyl-1H -pyrazol-3-yl)cyclopropyl)methanol, 27 mg, 0.08 mmol) in toluene (2 mL) under N2, (2-methylthiazol-5-yl)methanamine (13 mg, 0.096 mmol), Pd2(dba)3 (7 mg, 0.008 mmol), BINAP (7 mg, 0.012mmol) and Na01Bu (9 mg, 0.096 mmol) were added. After the reaction mixture was stirred at 85C for 4 h, 15 mL water was added. The mixture was extracted with EtOAc (3 x 10 mL). Thecombined organics were dried over MgS04, filtered and concentrated in vacuo. The residue was5 purified by reverse phase chromatography (X bridge Prep C180BD, 40-60% acetonitrile inwater with 10 mmol NH4HC03 modifier) to afford the title compound as an oil. 1H NMR (400MHz, MeOD) o 7.56 (s, 1H),7.42 (d, 1H), 5.96 (d, 1H), 5.89 (s, 1H), 4.59 (s, 2H), 4.15-5.11(m, 1H), 4.04-4.01 (m, 1H), 3.81 (s, 3H), 3.63 (s, 3H), 2.66 (s, 3H), 1.95- 1.89 (m, 1H), 1.61-1.53 (m, 1H), 1.01-0.95 (m, 2H); LRMS m/z (M+H) 387.1 found, 387.15 required.

The synthetic route of 63139-97-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; MCCOMAS, Casey C.; REGER, Thomas S.; QI, Changhe; WO2014/139150; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ethyl 3-(2-(6-chioro-3-cvano- 4-methyipyridin-2-yi)-5-fluoro- I ,2,3,4-tetrahydroisoquinolin-6-yI)propanoate (50 mg, 0.124 mrnol) and 4-(tributylstannyi)thiazoie (51.2 mg, 0.137 mrnol) in dioxane (3 ml) was added (i2 XPhos (979mg. 0.012 mmol). The mixture was stirred at 110 c for 12 h, then quenched with 10% aqueous KF (10 ml), filtered and extracted with ethyl acetate (8 niL x 3). The organic layers were combined and washed with water (15 mL), brine (10 mL), dried over Na2SO4,filtered and concentrated under reduced pressure to afford the title compound, which was used directly without further purification., 173979-01-6

173979-01-6 4-(Tributylstannyl)thiazole 2763258, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-amino-5-bromobenzenethiol (3) (10 g, 48.9 mmol) with thiazole-2-carbaldehyde (4) (4.3 mL, 48.9 mmol) and ZnO NPs (362 mg, 4.44 mmol) in absolute ethanol (40 mL) was stirred at room temperature for 8 min. After completion of the reaction (TLC), the solvent was evaporated in vacuum and the crude solid product was purified by column chromatography (ethyl acetate?hexane, 1 : 1) to give pure compound 5. Yield 93percent. 1H NMR spectrum, delta, ppm: 7.49 d (1H, J = 8.09 Hz), 7.68 d (1H, J = 8.10 Hz), 7.75 d (1H, J = 8.09 Hz), 7.84 d (1H, J = 8.10 Hz), 7.93 s (1H). MS (FAB): 298 [M]+.

10200-59-6, The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pragathi; Sreenivasulu; Veronica; Madhavi; Raju; Russian Journal of General Chemistry; vol. 89; 5; (2019); p. 1009 – 1014; Zh. Obshch. Khim.; vol. 89; 5; (2019); p. 1009 – 1014,6;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-79-9,2-Amino-4-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

5464-79-9, 2-Amino-4-methoxy-benzothiazole (1. 00 g, 5.54 mmol) was added to a stirred solution of polyphosphoric acid (85%, 40 ml) at 60 C. The resulting mixture was stirred at 60 C until all the benzothiazole had dissolved. The resulting solution was then cooled to-10 C and a solution of sodium nitrite (2.3 g, 33.3 mmol) in water (5 ml) was added so as to keep the internal temperature BELOW-4 C. After complete addition the resulting solution was added to a solution of hypophosphoric acid (50%, 15 ml) at 0 C. After the evolution of gas had ceased the mixture was diluted with water and basified with NAHC03 (sat). The aqueous solution was extracted with CHC13 (3 x 200 ML) with the combined organic extracts dried (MGSO4) and the solvent removed in vacuo. The resulting solid was recrystallised from EtOH: H20 to give an orange solid (300 mg). The liquor was concentrated and purified by flash chromatography eluting silica gel with hexane: EtOAc [4: 1] to hexane: EtOAc [1: 1] to give a further 210mg of product. RF = 0. 38 in hexane : ether [1 : 1] ; ON (300 MHz, CDC13) 8.91 (1H, s, CH), 7.53 (1H, d, Ar), 7.39 (1H, T, Ar), 6.93 (1H, d, Ar), 4.07 (3H, s, OCH3)

5464-79-9 2-Amino-4-methoxybenzothiazole 21622, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/43931; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

541-58-2, 2,4-Dimethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The light source was a medium-pressure mercury lamp (500W) in a glass cooling water jacket to cut off light of wavelengths shorter than 300nm. The solution of phthalimide (2mmol, 0.025M) and N-vinyllactams or methylthiazoles (10mmol) in dichloromethane (80ml) was purged with argon(Ar) for 15min and then irradiated under continuous Ar purging. The reaction course was monitored by TLC. After the reaction, the solvent was removed under reduced pressure and the residue was purified by flash chromatography on a silica gel column with petroleum ether/ethyl acetate as eluents (gradient elution)., 541-58-2

541-58-2 2,4-Dimethylthiazole 10934, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Shen, Yong-Miao; Grampp, Guenter; Tao, Fei-Fei; He, Ning-De; Chen, Da-Qing; Ye, Miao; Journal of Photochemistry and Photobiology A: Chemistry; vol. 271; (2013); p. 85 – 92;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1452-15-9,4-Cyanothiazole,as a common compound, the synthetic route is as follows.

General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Ya; Kirchmair, Johannes; Li, Xueyao; Ma, Guixing; Wu, Song; Xia, Jie; Xue, Wenjie; Zhang, Hongmin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica