With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1452-15-9,4-Cyanothiazole,as a common compound, the synthetic route is as follows.
General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification., 1452-15-9
1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Chen, Ya; Kirchmair, Johannes; Li, Xueyao; Ma, Guixing; Wu, Song; Xia, Jie; Xue, Wenjie; Zhang, Hongmin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica