With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2406-90-8,2-Chlorobenzo[d]thiazol-6-amine,as a common compound, the synthetic route is as follows.
Add oxalyl chloride (10 mL, 114.6 mmol) and DMF (4 drops) to a stirring suspension of4′-fluoro-biphenyl-4-carboxylic acid (4.9 g, 22.7 mmol) in CH2Cl2 (150 mL). Stir the reaction mixture at room temperature for 3 h. Concentrate the mixture in vacuo, add n-hexane, re- concentrate, and re-dissolve in CH2Cl2. Add the resultant 4′-fluoro-biphenyl-4-carbonyl chloride solution to a mixture of 2-chloro-benzothiazol-6-ylamine (3.31 g, 17.9 mmol) and pyridine (3.0 mL) in CH2Cl2 (150 mL). Stir the reaction mixture overnight at room temperature. Dilute the reaction mixture with CH2Cl2. Wash the reaction mixture twice with LOM HCl and once with LOM NaOH. Dry the mixture over Na2SO4, concentrate in vacuo, and triturate with MeOH to yield the desired product (6.34 g, 93%). 1H NMR (400 MHz, DMSO-d6): deltaltheta.59 (s, IH), 8.69 (d, J = 1.6Hz, IH), 8.09 (d, J= 8.0Hz, 2H), 7.96 (d, J = 8.8Hz, IH), 7.87-7.79 (m, 5H), 7.38-7.31 (m, 2H)., 2406-90-8
The synthetic route of 2406-90-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2006/66173; (2006); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica