With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.40004-69-1,2-Methyl-5-thiazolecarboxylic acid,as a common compound, the synthetic route is as follows.
Synthesis of (F); To a 0¡ã C. solution of Compound (D) (41 mmol) and 2-methyl-thiazole-5-carboxylic acid (E) (6.0 g, 42 mmol), HOBT (7.9 g, 50 mmol) and HBTU (18.0 g, 50 mmol) in tetrahydrofuran (800 mL) was added a solution of N,N-diethylisopropylamine (50 g) in tetrahydrofuran (200 mL) over 5 minutes until its pH reached approximately 8.5. The resulting mixture was stirred at same temperature overnight. It was then quenched with saturated aqueous sodium bicarbonate solution (200 mL), and most of the solvents were removed under reduced pressure. The residual mixture was extracted with ethyl acetate (3.x.400 mL). The combined organic layers were washed with saturated aqueous sodium bicarbonate (200 mL) and brine (100 mL), dried over sodium sulfate and filtered through Celite-545. The solvents were removed under reduced pressure and residue was purified by flash chromatography (silica gel, ethyl acetate with 2percent methanol). Compound (F) (17.1 g) was isolated and characterized by LC/MS (LRMS (MH) m/z: 436.15)., 40004-69-1
40004-69-1 2-Methyl-5-thiazolecarboxylic acid 98845, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Onyx Therapeutics, Inc.; US2010/240903; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica