Day: November 18, 2020

2933-29-1, 2-Amino-4,5,6,7-tetrahydrobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 134 S-5-Fluoro-1H-indole-2-carboxylic acid [2-phenyl-1-(4,5,6,7-tetrahydro-benzothiazol-2-ylcarbamoyl)-ethyl]-amide From S-2-[(5-fluoro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionic acid and 4,5,6,7-tetrahydro-benzothiazol-2-yl-amine. mp 162 – 165 C.

2933-29-1, 2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; EP1134213; (2001); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.155559-81-2,5-Fluorobenzo[d]thiazole-2-thiol,as a common compound, the synthetic route is as follows.

Example 40Preparation of7V,7V-dicyclopropyl-6-ethyl-4-(5-fluorobenzo[d]thiazol-2-ylamino)-l- methyl-l,6-dihydroimidazo [4,5-d] pyrrolo [2,3-b] pyridine-7-carboxamide 40A Preparation of 5-fluoro-2- methylthio)benzo|”d”lthiazole[00284] To a solution of 5-fluoro-2-mercaptobenzothiazole (0.15 g, 0.810 mmol) in THF (8.10 niL) cooled to 0 C was added sodium hydride (0.036 g, 0.891 mmol). After stirring 10 min, iodomethane (0.076 mL, 1.215 mmol) was added and the reaction mixture was slowly warmed to room temperature over 2 h. The reaction was diluted with ethyl acetate and quenched with saturated aqueous sodium bicarbonate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. 5-fluoro-2-(methylthio)benzo[d]thiazole (0.178 g, 110 % yield) was isolated as a white solid. Material was used without any further purification.[00285] MS (ESI) m/z 200.0 (M+H)[00286] 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.68 (dd, 1H, J= 8.81, 5.04 Hz), 7.56 (dd, 1H, J= 9.57, 2.52 Hz), 7.07 (td, 1H, J= 8.81, 2.52 Hz), 2.80 (s, 3H), 155559-81-2

The synthetic route of 155559-81-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; PURANDARE, Ashok V.; GREBINSKI, James W.; HART, Amy; INGHRIM, Jennifer; SCHROEDER, Gretchen; WAN, Honghe; WO2011/28864; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

19759-66-1, 2-Aminobenzothiazole-6-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of benzofurane-2-carbonyl chloride 1 in dry toluene, a solution of corresponding anilines and amino-pyridines 2a-j, 2-aminobenzothiazoles 4a, 4c and 5a and 2-aminobenzimidazoles 4b, 4d and 5b in dry toluene was added dropwise, followed by the addition of Et3N. The mixture was refluxed for several hours. After cooling, the resulting products were filtered off and recrystallized from methanol to obtain benzofurane-2-carboxamides 3a, 3b, 3d-j and 6a-f., 19759-66-1

As the paragraph descriping shows that 19759-66-1 is playing an increasingly important role.

Reference£º
Article; Hranjec, Marijana; Sovic, Irena; Ratkaj, Ivana; Pavlovic, Gordana; Ilic, Natasa; Valjalo, Linda; Pavelic, Kresimir; Kraljevic Pavelic, Sandra; Karminski-Zamola, Grace; European Journal of Medicinal Chemistry; vol. 59; (2013); p. 111 – 119;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-01-2,Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

A solution of compound NL (1.03mmol, 300mg, obtained from the method previously reported) [16] in 9 CH2Cl2 (20mL) and 10 Et3N (0.5mL) were added to a round-bottom flask. The mixture was stirred in an ice-water bath. A solution of 11 2,4-dinitrobenzene sulfonyl chloride (1.24mmol, 330mg) in CH2Cl2 (10mL) was added to the mixture dropwise over 0.5h. The mixture was stirred at 0¡ãC for 1h. The mixture then continued to be stirred at room temperature for 2h until thin layer chromatography indicated the reaction was complete. The organic phase was washed with 60mL of 12 water (3¡Á20mL) and then dried over MgSO4. The solvent was concentrated under reduced pressure. The crude material was purified by column chromatography on silica gel (eluted with hexanes to 13 ethyl acetate: hexane=1:4) to afford a yellow solid of 14 NL-S in 36.9percent yield (197mg, 0.38mmol). Melting point: 185.4?186.0¡ãC. 1H NMR (600MHz, DMSO?d6): delta 10.12 (s, 1H, -CHO), 9.12 (d, J=2.4Hz, 1H, ph-H), 8.63 (dd, J=8.4, 2.4Hz, 1H, ph-H), 8.46 (d, J=2.4Hz, 1H, ph-H), 8.35 (d, J=3Hz, 1H, ph-H), 8.28 (dd, J=8.1, 2.7Hz, 1H, ph-H), 7.40 (d, J=9Hz, 1H, ph-H), 4.29 (m, 2H, -CH2-), 2.68 (s, 3H, thiazole-CH3), and 1.29 (t, J=7.1Hz, 3H, -CH3). 13C NMR (150MHz, DMSO?d6): delta 188.06, 166.33, 161.59, 160.86, 152.17, 150.23, 148.54, 140.36, 134.32, 133.97, 132.68, 130.85, 129.99, 128.72, 128.17, 125.05, 121.68, 61.89, 17.60, and 14.54. High-resolution mass spectrometry (HRMS): m/z [M + Na]+ calcd. for [C20H15N3O10S2+Na]+: 544.0091, found: 544.0090. IR (KBr, cm?1): 3417.39, 3105.18, 2925.38, 1709.48, 1603.25, 1556.83, 1542.6, 1373.73, 1350.08, 1258.92, 1202.38, 1169.51, 1098.66, 887.35, 831.21, 710.78, 614.90, and 561.00., 161798-01-2

As the paragraph descriping shows that 161798-01-2 is playing an increasingly important role.

Reference£º
Article; Wang, Yi; Wang, Lijun; Jiang, Erkang; Zhu, Meiqing; Wang, Zhen; Fan, Shisuo; Gao, Qian; Liu, Shangzhong; Li, Qing X.; Hua, Rimao; Dyes and Pigments; vol. 156; (2018); p. 338 – 347;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.777-12-8,6-(Trifluoromethyl)benzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

Example 2: General procedure for synthesis of compounds 24 and 46. (0108) (0109) General methodology: In a microwave vial benzothiazole derivative and the corresponding isocyanate is added in each case. Next, THF is added as solvent. The vial is introduced into the microwave reactor and heated to the temperature for the time indicated in each case. After the reaction time, ethyl acetate (50 mL) and water (50 mL) is added. The organic phase is dried over anhydrous MgS04 and the solvent is removed under reduced pressure. The obtained residue was purified by flash column chromatography using Isolera One equipment, in all cases a mixture of hexane and ethyl acetate as eluent was used. N-(6-trifluoromethylbenzothiazole-2-yl)-N’-(3-chlorophenyl)urea (24): (0110) Reagents: 1-isocianato-3-chlorobenzene (175.8 mg, 1.2 mmol), 2-amino-6-trifluoromethylbenzothiazole (250 mg, 1.2 mmol) and THF (0.4 mL). Reaction conditions: 3 hours and 30 min under microwave irradiation at 110¡ãC. Purification by flash column chromatography using hexane/ethyl acetate (3:1) to obtain a white solid. Yield: 43.2 mg, 10percent. Mp: 222¡ãC-223¡ãC 1H NMR (500 MHz, DMSO-d6) delta: 11.16 (s, 1 H), 9.38 (s, 1 H), 8.41 (s, 1 H), 7.73 (s, 1 H), 7.69 (dd, J = 8.5, 1.9 Hz, 1 H), 7.38 (s, 1 H), 7.35 (t, J = 7.9 Hz, 2H), 7.11 (d, J = 8.5 Hz, 1H). 13C NMR (126 MHz, DMSO-d6) delta: 162.6, 152.0, 140.3, 133.7, 131.0, 125.0 (q, J = 271.7 Hz), 123.6 (d, J = 31.8 Hz), 123.5, 123.4 (d, J = 2.5 Hz), 120.1 (d, J = 4.3 Hz), 118.8, 117.9. HPLC purity: >99percent. MS (ES) m/z: 372 [M+H]+., 777-12-8

777-12-8 6-(Trifluoromethyl)benzo[d]thiazol-2-amine 2735955, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Consejo Superior De Investigaciones Cientificas (CSIC); MARTINEZ GIL, Ana; PEREZ FERNANDEZ, Daniel Ignacio; GIL AYUSO-GONTAN, Carmen; GARCIA SALADO, Irene; REDONDO SANCHO, Miriam; PEREZ MARTINEZ, Concepcion; EP2949651; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

344-72-9, Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 39 Preparation of Ethyl 2-Iodo-4-Trifluoromethyl-5-Thiazolecarboxylate To a cold (-5 C.) solution of 4.0 g (0.0166 mole) of ethyl 2-amino-4-trifluoromethyl-5-thiazolecarboxylate, prepared according to U.S. Pat. No. 2,726,237, in 30 ml. of 85% phosphoric acid and 30 ml. of 70% nitric acid was added a solution of 1.26 g (0.0166 mole) of sodium nitrite in 10 ml. of water in 10 minutes. The reaction mixture was stirred for 10 minutes and poured into a solution of 10 g of potassium iodide in 100 ml. of water. The reaction mixture was stirred overnight and extracted with ether. The ether solution was dried and concentrated and the residue was chromatographed on silica gel to give 1.5 g of the desired product, m.p. 75-76 C. Anal. Calc’d. for C7 H5 F3 INO3 S: C, 23.94; H, 1.44; N, 3.99; I, 36.15. Found: C, 23.93; H, 1.44; N, 3.95; I, 36.08.

344-72-9, The synthetic route of 344-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Monsanto Company; US4437875; (1984); A;; ; Patent; Monsanto Company; US4437876; (1984); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

16311-69-6, 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,5-dimethyl-4-(hydroxyethyl) thiazolium iodide (2.5 mmol, 700 mg), methylsulfonyl chloride (3 mmol, 0.25 ml) and triethylamine (5 mmol, 0.35 ml) in CH3CN(20 ml) was stirred at 0 C for 2 h, under argon. After rotary evaporation, the crude product was dissolved in ethanol (25 ml). Potassium thioacetate (3 mmol, 343 mg) was added dropwise and the mixture was allowed to reflux for 72 h. The product mixture was rotary evaporated to dryness, then the resultant crude solid was dissolved in formic acid (5 ml). Performic acid was generated by stirring hydrogen peroxide (14 mmol, 1.8 ml) and formic acid (30 mmol, 1.4 ml) at room temperature for 1 h. The performic acid solution was cooled to 0 C and added to the reaction mixture. The mixture was left stirring for 48 h. Excess solvent was removed by rotary evaporation and the final crude product was purified by HPLC. 1H NMR (300 MHz,DMSO-d6) delta 9.90 (s, H), 4.05 (s, 3 H), 3.14-3.19 (t, J = 7.1 Hz, 2 H),2.70-2.75 (t, J = 7.0 Hz, 2 H), 2.41 (s, 3 H).

16311-69-6, 16311-69-6 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide 9838770, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Zeng, Hao; Wang, Kai; Tian, Yuan; Niu, Yijie; Greene, Landon; Hu, Zhichao; Lee, Jeehiun K.; International Journal of Mass Spectrometry; vol. 378; (2015); p. 169 – 174;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: To a solution of carboxylic acid (1 mmol) in CH2Cl2 (10 ml) were added Et3N (2 mmol) and TBTU (1.1 mmol) and the mixture was stirred at room temperature for 15 min. Then amine 1 or 3 (1 mmol)and Et3N (2 mmol) were added and the reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture was diluted with CH2Cl2 (15 ml) and washed with saturated aqueous NaHCO3 solution (2×15 ml). Combined water phases were extracted with CH2Cl2 (1 20 ml). Combined organic phases weredried over Na2SO4, filtered and the solvent removed under reduced pressure.

106092-09-5, The synthetic route of 106092-09-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hodnik, ?iga; Toma?i?, Tihomir; Ma?i?, Lucija Peterlin; Chan, Fiona; Kirby, Robert W.; Madge, David J.; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 154 – 164;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81449-93-6,Ethyl 2-chlorothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Dissolve ethyl 2-CHLOROTHIAZOLE-5-CARBOXYLATE (0.927 g, 4. 84 mmol) in methanol. Cool the solution to 0 C, then bubble NH3 into the reaction mixture for 10 minutes. Then seal the reaction vessel and stir for 3 hours. Concentrate the reaction mixture to give the title product : LH NMR (CDC13) : 8. 21 (s, 1H), 8.19 (s, 1H), 7.77 (s, 1H) ; HPLC [YMC-Pro pack C-18 (150 x 4.6 mm, S-5 microm), 0.05% TFA/acetonitrile in 0.05% TFA/WATER at 1.0 ML/MIN, 10-20% over 5 min, 20-95% over 18], tR = 6.9 min, 100% purity, 81449-93-6

Big data shows that 81449-93-6 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/80996; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.440100-94-7,2-Bromothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

i) To a solution of palladium (II) trifluoroacetate (66.0 mg, 0.20 mmol) and tri-t- butylphosphonium tetrafluoroborate (58.0 mg, 0.20 mmol) in anhydrous toluene (10 mL) under an argon atmosphere was added 2-bromo-l,3-thiazole-5-carbonitrile (756 mg, 4.00 mmol) followed by potassium phosphate tribasic (934 mg, 4.40 mmol) then tert-butyl piperazine-1-carboxylate (3.00 g, 16.00 mmol). The reaction mixture was heated at 8O0C for 16 hours. The reaction mixture was diluted with EtOAc (100 mL), water (100 mL) and the layers separated. The aqueous layer was extracted with EtOAc (100 mL), the combined organics washed with water (100 mL) and dried (MgSO4) to give a crude gum. The crude material was purified by flash column chromatography (isohexane to 50 % ethyl acetate then to ethyl acetate) to furnish the desired compound as a white solid (1.00 g, 85 % yield). MS (+ve ESI) (des Boc material) : 195 (M+H)+1R NMR (400.13 MHz, CDCl3) delta 1.48 (s, 9H), 3.57 (m, 8H), 7.69 (s, IH), 440100-94-7

As the paragraph descriping shows that 440100-94-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/1127; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica