344-72-9, Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 39 Preparation of Ethyl 2-Iodo-4-Trifluoromethyl-5-Thiazolecarboxylate To a cold (-5 C.) solution of 4.0 g (0.0166 mole) of ethyl 2-amino-4-trifluoromethyl-5-thiazolecarboxylate, prepared according to U.S. Pat. No. 2,726,237, in 30 ml. of 85% phosphoric acid and 30 ml. of 70% nitric acid was added a solution of 1.26 g (0.0166 mole) of sodium nitrite in 10 ml. of water in 10 minutes. The reaction mixture was stirred for 10 minutes and poured into a solution of 10 g of potassium iodide in 100 ml. of water. The reaction mixture was stirred overnight and extracted with ether. The ether solution was dried and concentrated and the residue was chromatographed on silica gel to give 1.5 g of the desired product, m.p. 75-76 C. Anal. Calc’d. for C7 H5 F3 INO3 S: C, 23.94; H, 1.44; N, 3.99; I, 36.15. Found: C, 23.93; H, 1.44; N, 3.95; I, 36.08.
344-72-9, The synthetic route of 344-72-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Monsanto Company; US4437875; (1984); A;; ; Patent; Monsanto Company; US4437876; (1984); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica