57268-16-3, 5-Bromo-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
57268-16-3, A sol. of intermediate 7 (0.070 g, 0.14 mmol), 5-bromo-2-methylthiazole (0.051 g, 0.29 mmol), Cs2CO3 (0.047 g, 0.14 mmol), Pd(PPh3)4 (0.033 g, 0. 29 mmol) and a 3 N NaOH aq. sol. (0.024 ml, 0.07 mmol) in 1,4-dioxane (10 ml) was purged with N2 for 2 min. The r.m. was stirred at 80 0C overnight. After cooling, H2O was added and the product was extracted with DCM. The organic phase was washed with brine, dried (Na2SO4) filtered and concentrated under reduced pressure. The residue was purified by preparative HPLC [RP Shandon Hyperprep Cl 8 BDS (8 mum, 250 g, LD. 5 cm); mobile phase: (0.25 % NH4CO3 sol. in water, MeOH + CH3CN)]. The product fractions were collected and concentrated under reduced pressure. Yield: 0.013 g of compound 4 (19.7 %).
57268-16-3 5-Bromo-2-methylthiazole 13228663, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; VELTER, Adriana, Ingrid; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; WU, Tongfei; VAN BRANDT, Sven, Franciscus, Anna; SURKYN, Michel; ZAJA, Mirko; PIETERS, Serge, Maria, Aloysius; BERTHELOT, Didier, Jean-Claude; DE CLEYN, Michel, Anna, Jozef; OEHLRICH, Daniel; WO2010/89292; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica