72850-79-4, Ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72850-79-4
A mixture of 2-bromothiazole 8 (152 mg, 0.50 mmol), Et3N (0.28 mL, 2.0 mmol, 4.0 equiv) and the appropriate isothiouronium salt (233 mg, 1.0 mmol, 2.0 equiv) were heated using MW irradiation at 130 C for 30 mins. The solvent was removed under reduced pressure and the orange residue was reconstituted in EtOH (5 mL) and treated with LiOH¡¤H2O (107 mg, 2.55 mmol, 5.1 equiv) for 5 h. The reaction mixture was concentrated under reduced pressure and partitioned between CH2Cl2 (10 mL) and H2O (10 mL). The isolated aqueous phase was made acidic (pH = 1) using 2 M HCl (ca. 3 mL) and extracted using CH2Cl2/EtOH (9:1, 4 ¡Á 10 mL). The combined organic extract was dried (MgSO4), filtered and concentrated to give the title compound (75 mg, 43%) as a white powder;
72850-79-4 Ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate 13282759, athiazole compound, is more and more widely used in various fields.
Reference£º
Article; Hickey, Shane M.; White, Jonathan M.; Pfeffer, Frederick M.; Ashton, Trent D.; Synlett; vol. 26; 12; (2015); p. 1759 – 1763;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica