With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38205-60-6,1-(2,4-Dimethylthiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.
Example 111-[N,N-dimethylaminocarbonyl-methyl]-2-[2-(2,4-dimethylthiazol-5-yl)-quinolin- 6-yl]-3-cyclohexyl-1H-indole-6-carboxylic acid (Compound 212) Preparation of 6-bromo-2-(2,4-dimethyl-thiazol-5-yl)-quinoline (125): [0217] A mixture of 1.071 g (5.354 mmol) compound 110, 723 muL (5.354 mmol) 5- acety1-2,4-dimethylthiazole and 9.0 mL 10% KOH/ethanol (16.062 mmol KOH) in 60 mL ethanol was refluxed overnight under argon. It was then evaporated and the residue triturated with water. The solid crude product was filtered through a 250 mL silica pad using a 10% to 60% toluene-ethylacetate gradient to give 1.164g (68%) compound 125,1H-NMR (DMSO-d6): delta(ppm) 8.39 (d, 1H, J=8.7Hz), 8.27 (m, 1H), 7.88-7.86 (m, 3H), 2.68 (s, 3H), 2.64 (s, 3H).; Example 88 Step 1. 6-Bromo-2-(2,4-dimethyl-thiazol-5-y1)-quinoline (125)[0307] To a solution of KOH (10.32 (85%) g, 156.27 mmol) in anhydrous EtOH (700 mL) was added 2-amino-5-bromobenzaldehyde (10.42 g, 52.09 mmol) and 5-acety1- 2,4-dimethylthiazole (8.16 mL, 60.42 mmol). The mixture was stirred under Ar at 78 0C for 16 h and then cooled down in an ice-bath. It was neutralized to pH 7 with 5 N HCl and then evaporated to about 60 mL. Water (500 mL) was added. The precipitate formed were collected by filtration, washed thoroughly with water, and dried to give 125 (15.62 g, 94%).
38205-60-6, The synthetic route of 38205-60-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENELABS TECHNOLOGIES, INC.; WO2006/76529; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica