Day: November 20, 2020

432047-36-4, 1-(2-Thiazolyl)ethylamine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,432047-36-4

Example 84: N-[4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)phenyl]-N’-[(1S)-1-(1,3-thiazol-2-yl)ethyl]urea 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)aniline (30 mg) was dissolved in chloroform (1 ml) and triethylamine (0.1 ml) to prepare a solution. A solution of triphosgene (35 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for one hr. Next, a solution of (1S)-1-(1,3-thiazol-2-yl)-1-ethylamine (35 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (29 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): delta 1.70 (d, J = 6.8 Hz, 3H), 4.07 (s, 3H), 4.10 (s, 3H), 5.34 – 5.41 (m, 1H), 6.26 (d, J = 6.8 Hz, 1H), 6.58 (d, J = 5.9 Hz, 1H), 7.16 (s, 1H), 7.30 (d, J = 3.2 Hz, 1H), 7.37 (dd, J = 2.9, 9.0 Hz, 1H), 7.44 (d, J = 2.7 Hz, 1H), 7.55 (s, 1H), 7.72 (d, J = 3.4 Hz, 1H), 7.75 (br, 1H), 8.23 (d, J = 9.0 Hz, 1H), 8.51 (d, J = 5.9 Hz, 1H)

The synthetic route of 432047-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1535910; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Weigh tert-butyl ((R)-2-hydroxy-2-phenylethyl) (4-((S)-pyrrolidine-2-carboxamido)phenethyl)carbamate (500 mg, 1.10 Mm),Ethyl 2-bromo-4-methyl-thiazole-5-carboxylate(330 mg, 1.32 mmol),Potassium carbonate (461 mg, 3.30 mmol) in a 100 mL single-mouth bottle,Add acetonitrile (15 mL) and start to reflux at 90 ¡ã C, and stop the reaction for 10 hours.The reaction mixture was concentrated, and the residue was purified by column chromatography ( petroleum ether/ethyl acetate (v/v) = 2/1)The title compound was obtained as a white solid(430 mg, 63percent).

22900-83-0, 22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhong Wenhe; Jin Chuanfei; Xu Tengfei; (45 pag.)CN109734712; (2019); A;,
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34272-64-5, 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Each resin from Step 3 was distributed into 24 fritted syringes (Torvig, 50 mg each, 50 mumol), for a total of 96 syringes, and was swelled in NMP (1 mL) for 30 min. The solvent was removed by filtration. Twenty-four solutions of the building blocks listed below (10 mmol each) and DIBA (3.5 mL, 20 mmol) in NMP (10 mL) were prepared. 3 mL of the 24 solutions was added to the 24 syringes for each resin from Step 3, accordingly. The suspensions were then shaken for 20 h on a Titer Plate Shaker. The reaction mixture was filtered and washed 5 times with methylene chloride (5 mL), 3 times with THF (5 mL), 3 times THF/H2O (3/1 v/v, 5 mL), and 3 times with THF (5 mL). The resins were then dried overnight under vacuum., 34272-64-5

The synthetic route of 34272-64-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kong, Xianqi; Wu, Xinfu; Valade, Isabelle; Gervais, Francine; US2006/167057; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53572-98-8,Imidazo[2,1-b]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of the respective carboxylic acid (0.030 mmol, 1.8 eq) in DMF (0.25 mL) is added successively a solution of DIPEA (0.075 mmol, 4.4 eq) in DMF (0.15 mL) and a solution of TBTU (0.030 mmol, 1.8 eq) in DMF (0.15 mL). The obtained mixture is treated with a solution of the respective 3-aza-bicyclo[3.1.0]hexane derivative (0.017 mmol, 1.0 eq, free base) in DMF (0.15 mL). The mixture is shaken over night and purified by prep. HPLC to give the respective amide derivatives. prepared by reaction of [(1R*,2S*,5S*)-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with imidazo[2,1-b]thiazole-6-carboxylic acid. LC-MS: tR=0.84 min; [M+H]+=478.1., 53572-98-8

The synthetic route of 53572-98-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Actelion Phamaceuticals Ltd.; US2010/16401; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 4 (4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-carbamic acid isobutyl ester Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine and isobutanol, the title compound was obtained as yellow crystals (12% yield). MS: m/e=366(M+H+), mp 164-168 C.

383865-57-4, The synthetic route of 383865-57-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Flohr, Alexander; Jakob-Roetne, Roland; Norcross, Roger David; Riemer, Claus; US2004/235842; (2004); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of A (10 g, 48 mmol) in THF (50 mL) at 0C under nitrogen was added aq.NaOH (72ml, 2M, 145 mmol). Reaction mixture was stirred at room temperature for 30-120min, monitored by TLC. Mixture was acidified with aq.HCl (6M) to pH=3-4, and precipitate filtered to give 1 (7 g, 81%) as a white solid., 32137-76-1

32137-76-1 Ethyl 1,3-benzothiazole-2-carboxylate 640708, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; CHATTERJEE, Arnab, K.; WANG, Feng; SCHULTZ, Peter, G.; XU, Chunping; AJAYI, Kehinde; WANG, Jianing; HALDER, Rajkumar; KUMAR, Puneet; YANG, Baiyuan; LIU, Renhe; CHENG, Bo; KANEKO, Takushi; WO2014/190199; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61830-21-5,Ethyl 2-amino-5-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,61830-21-5

General procedure: A mixture of 2-amino-5-bromothiazole-4-carboxylate (34, 2.22g,0.01 mol), the appropriate 2-thioxo-quinazoline analogs (14-17,0.01 mol), anhydrous potassium carbonate (1.5 g, 0.01 mol) in DMF(10 ml) was heated under reflux for 14-16 h. Solvent was then removed under reduced pressure and continued as mentioned under compounds 21-24 (Table 1).

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Al-Omary, Fatmah A.M.; Hassan, Ghada S.; El-Messery, Shahenda M.; Nagi, Mahmoud N.; Habib, El-Sayed E.; El-Subbagh, Hussein I.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 33 – 45;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3704-41-4, 2-(4-Nitrophenyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-(4-nitrophenyl)thiazole (6 g, 29.10 mmol, 1 eq.) in DMF (50 mL), was added NBS (15.54 g, 87.29 mmol, 3 eq.). The mixture was stirred at 80C for 15 mins and LCMS showed the reaction was complete. The mixture was poured into water (1L) and filtered. The filter cake was washed with MeOH (50 mL) and dried to give 5-bromo-2- (4- nitrophenyl)thiazole (7.3 g, crude) as a yellow solid. 1H NMR (400MHz, METHANOL-d4) delta = 8.35 (br s, 2H), 8.18 (br s, 2H), 8.07 – 7.88 (m, 1H).

3704-41-4, 3704-41-4 2-(4-Nitrophenyl)thiazole 13546655, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; CYTEIR THERAPEUTICS, INC.; CASTRO, Alfredo, C.; MCCOMAS, Casey, Cameron; VACCA, Joseph; (214 pag.)WO2019/14315; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7336-54-1,N-(5-bromothiazol-2-yl)acetamide,as a common compound, the synthetic route is as follows.,7336-54-1

EXAMPLE 79 A mixture of 2-acetylamino-5-bromothiazole (2.2 g), 4-amino-2-mercaptopyrimidine (1.3 g) and potassium carbonate (2.0 g) in N,N-dimethylformamide (50 ml) was heated at 90 C. for 2 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was triturated with water. The precipitation was collected by filtration, washed with water and dried in vacuo to give solid. The solid was subjected to column chromatography on silica gel (silica gel 60, 70-230 mesh; Merck: 200 g) and eluted with a mixture of chloroform and methanol (10:1). The fractions containing the objective compound were combined and concentrated under reduced pressure to give 2-acetylamino-5-(4-aminopyrimidin-2-ylthio)thiazole (1.3 g, yield: 48.7%). mp: 255-258 C. (dec.) IR (Nujol): 3400, 3350, 3200, 1692, 1650, 1585, 1325, 1300 cm-1 NMR (DMSO-d6, 200 MHZ, ppm): 2.16 (3H, s), 6.17 (1H, d, J=6Hz), 7.02 (2H, s), 7.59 (1H, s), 7.85 (1H, d, J=6Hz), 12.31 (1H, s) Mass: M+1 268, M 267, m/e 225, 205, 183

As the paragraph descriping shows that 7336-54-1 is playing an increasingly important role.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5256675; (1993); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

137-00-8, 4-Methyl-5-thiazoleethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-(2-hydroxyethyl)-4-methylthiazole 7 (3.0 g, 21.0 mmol) and methyl iodide (2.64 mL, 42.0 mmol) were mixed and refluxed for 2 h. After evaporation of excess methyl iodide, to the residual brown syrup was added ether (50 mL) and stirred for 30 min, the precipitate was filtered to get 17 as a pale-yellow solid (5.76 g, 96.3%). Mp: 82-84 C; 1H NMR (D2O, ppm): 4.14 (s, 3 H, CH3N), 3.90 (t, 2 H, CH2CH2O, J = 5.6 Hz), 3.19 (t, 2 H, CH2CH2O, J = 6.0 Hz), 2.53 (s, 3 H, CCH3).

137-00-8, The synthetic route of 137-00-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fan, Wei; Wu, Yong; Li, Xian-Kun; Yao, Nian; Li, Xun; Yu, Yong-Guo; Hai, Li; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 3651 – 3661;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica