With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
Weigh tert-butyl ((R)-2-hydroxy-2-phenylethyl) (4-((S)-pyrrolidine-2-carboxamido)phenethyl)carbamate (500 mg, 1.10 Mm),Ethyl 2-bromo-4-methyl-thiazole-5-carboxylate(330 mg, 1.32 mmol),Potassium carbonate (461 mg, 3.30 mmol) in a 100 mL single-mouth bottle,Add acetonitrile (15 mL) and start to reflux at 90 ¡ã C, and stop the reaction for 10 hours.The reaction mixture was concentrated, and the residue was purified by column chromatography ( petroleum ether/ethyl acetate (v/v) = 2/1)The title compound was obtained as a white solid(430 mg, 63percent).
22900-83-0, 22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhong Wenhe; Jin Chuanfei; Xu Tengfei; (45 pag.)CN109734712; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica