Day: November 23, 2020

14542-12-2, Thiazol-2-ylmethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Manufacturing Example 88-1-2 2-Chloromethyl-thiazole; To a mixture of thiazole-2-yl-methanol (251 mg, 2.18 mmol) described in Manufacturing Example 88-1-1 and dichloromethane (10 mL) was added thionyl chloride (191 muL, 2.62 mmol) at room temperature, which was stirred for 30 minutes. Saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture, which was then extracted with dichloromethane. The organic layer was separated, washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (220.5 mg, 76%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 5.11 (2H, s), 7.81-7.83 (2H, m).

14542-12-2, 14542-12-2 Thiazol-2-ylmethanol 2795213, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.117043-86-4,4-(Aminomethyl)thiazole Hydrochloride,as a common compound, the synthetic route is as follows.

To a solution of thiazol-4-ylmethanamine hydrochloride (100 mg, 0.664 mmol) in acetonitrile (3 mL), potassium carbonate (229 mg, 1.66 mmol) and DMF (2 mL) were added. After the mixture was cooled to a temperature between -10 C. and -15 C., ethyl 2-bromoacetate (73 muL, 0.66 mmol) diluted with acetonitrile (1 mL) was added dropwise thereto. The temperature was gradually raised to room temperature, and the mixture was stirred overnight. Insoluble matters were separated by filtration, and the filtrate was concentrated under reduced pressure., 117043-86-4

As the paragraph descriping shows that 117043-86-4 is playing an increasingly important role.

Reference£º
Patent; Ajinomoto Co., Inc.; MATSUMOTO, Kayo; MIYANAGA, Wataru; DOHI, Mizuki; NAKAGAWA, Tadakiyo; KOBAYASHI, Kaori; TAKESHITA, Sen; (67 pag.)US2016/46592; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

20949-84-2, 4-Formyl-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 51 6-FLUORO-2-[2-(2-METHYL-THIAZOL-4-YL)-VINYL]-3-(2-METHYL-PHENYL)-3H-QUINAZOLIN-4-ONE Anhydrous zinc chloride (0.136 g, 1.0 mmol) was fused with a nitrogen purge in a round bottom flask with an open flame. The reaction vessel was allowed to return to ambient temperature, then dioxane (10 mL) was added. To this mixture was added 6-fluoro-2-methyl-3-(2-methyl-phenyl)-3H-quinazolin-4-one (0.1 34 g, 0.5 mmol), acetic anhydride (0.141 mL, 1.5 mmol), and 2-methylthiazole-4-carboxaldehyde (0.191 g, 1.5 mmol). The reaction was refluxed 3.5 hours, at which time the reaction was allowed to cool to ambient temperature. Once the reaction had cooled to ambient temperature it was diluted with water. The resulting mixture was repeatedly extracted with chloroform. The chloroform extracts were combined and the resulting chloroform layer was washed with water and brine, dried over sodium sulfate and concentrated to leave a dark residue. This residue was triturated with ether, filtered and dried to afford 0.04 g (21%) of 6-fluoro-2-[2-(2-methyl-thiazol-4-yl)-vinyl]-3-(2-methyl-phenyl)-3H-quinazolin-4-one as a tan solid. Melting point: 211-212 C.; NMR delta 7.91 (dd, J=3, 8.3 Hz, 1 H), 7.87 (d, J=15 Hz, 1 H), 7.75 (dd, J=5, 9 Hz, 1 H), 7.49 (dt, J=3, 9 Hz, 1 H), 7.42 (sym m, 3 H), 6.61 (d, J=15 Hz, 1 H), 2.60 (s, 3 H), 2.09 (s, 3 H)., 20949-84-2

20949-84-2 4-Formyl-2-methylthiazole 2763191, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US6306864; (2001); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4175-77-3, 2,4-Dibromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) Synthesis of 4-bromothiazol A solution of 10.0 g (41.2 mmol) 2,4-dibromothiazol in ether (210 ml) was cooled to -78 C. and 28.3 ml (45.3 mmol, 15% in hexane) n-butyllithium was added in drops at this temperature. After 30 min of stirring, 3.3 ml (82.3 mmol) methanol was added at -78 C. to the reaction mixture. Heating was subsequently performed to RT over a period of 16 h. The reaction mixture was filtered over silica gel and washed with a n-hexane/AE mixture (2:1). The filtrate was concentrated in a vacuum, whereby 6.7 g (40.9 mmol, 99%) 4-bromothiazol was obtained.

4175-77-3, The synthetic route of 4175-77-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Grunenthal GmbH; US2008/261996; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

913836-22-3, Methyl 5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

913836-22-3, In an oven-dried vial, methyl 5-bromothiazole-4-carboxylate (200 mg, 0.90 mmol) was dissolved in MeCN (2.4 mL). Morpholine (87 uL, 0.99 mmol) and DBU (0.2 mL, 1.35 mmol) were added to the vial sequentially. The vial was sealed and heated to 80 C for 5 hours. Cool the vial to room temperature and quench with water. Extract aqueous layer (3x) with EtOAc. The organic layer was dried with Na2SO4, filtered and concentrated. The crude product was purified on silica gel (hexane/EtOAc: 0% to 80%), affording methyl 5- morpholinothiazole-4-carboxylate (120 mg, 58%) as a white solid. ESI MS m/z = 229.1 [M+H]+.

As the paragraph descriping shows that 913836-22-3 is playing an increasingly important role.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; SHOOK, Brian, C.; KIM, In, Jong; BLAISDELL, Thomas, P.; YU, Jianming; PANARESE, Joseph; LIN, Kai; RHODIN, Michael, H.J.; McALLISTER, Nicole, V.; OR, Yat, Sun; (447 pag.)WO2019/67864; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4175-76-2,4175-76-2, 2,4-Dichlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,4-Dichlorothiazole (10 g, 64.9 mmol) was dissolved in acetic acid (50.0 ml) and heated to 60 C. Bromine (15.05 ml, 292 mmol) was added dropwise and the reaction mixture then stirred at 90 C. for 5.5 hours. The reaction was cooled to room temperature and made basic by slow addition of solid sodium carbonate, then diluted with water (100 mL) and extracted with Et2O (3*150 ml). The combined organic extracts were washed with sat.aq. sodium thiosulfate (50 ml) dried over sodium sulfate evaporated under reduced pressure to afford the title compound as a pale yellow oil. LC-MS Rt 1.43 min [M+H]+ 275.9/277.9/279.9/281.9 (Method 2minLowpHv03)

The synthetic route of 4175-76-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; BLOOMFIELD, Graham Charles; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPERD, Jon; WRIGHT, Paul; US2014/171412; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14542-16-6, 4-Methylthiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-methylthiazole-2-carboxylic acid (50.0 mg, 0.349 mmol) and CDI (84.9 mg,0.524 mmol) in THF (5.0 mL) was stirred at room temperature for 1 h, 2-amino-6-methylpyridine (37.7 mg, 0.349 mmol) was added. The mixture was stirred at room temperature for 2 h. The subsequent mixture was concentrated under reduced pressure and extracted with H2O/ethyl acetate. The combined organic layer was dried over Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 10:1) to afford the title compound 6ae (55 mg, 57 %) as white solid; 1H-NMR (400MHz, CDCl3) delta 9.61(s, 1H), 8.12 (d, J = 8 Hz, 1H), 7.63(t, J = 8 Hz, 1H), 7.18 (d, J = 0.8, 1H), 6.93 (d, J = 7.2, 1H), 2.49 (d, J = 1.2, 1H). 13C-NMR (100MHz, CDCl3) delta 162.0, 157.7, 157.2, 154.4, 150.0, 138.7,120.4, 119.6, 110.9, 24.1, 17.0. LC/MS (ESI-) 234.1 (M+H)+., 14542-16-6

The synthetic route of 14542-16-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.121-66-4,5-Nitrothiazol-2-amine,as a common compound, the synthetic route is as follows.,121-66-4

Example 1 Preparation of N-(5-Nitro-thiazol-2-yl)-2-pyridin-3-yl-acetamide (compound 13) To a solution of 3-Pyridylacetic acid hydrochloride (2.076 g, 12 mmol) in anhydrous THF, 1.5 equivalents of CDI (18 mmol, 2.916 g) in anhydrous THF and 1 equivalent of NEt3 (1.66 mL) are added. The resulting mixture is allowed to stir at room temperature for 4 hours. Then, 2-amino-5-nitro-thiazol (12 mmol, 1.740 g) in THF is added to the reaction mixture and this is stirred at room temperature for 10 h. When the reaction is completed, the solvent is evaporated and the resulting brown crude is dissolved in CH2Cl2 and water. This mixture produces a yellow precipitate, which is filtered and washed with water to obtain the desired compound as a yellow solid (2.300 g, yield: 73 %, 265 M+). 1H-NMR (DMSO): 3.95 (s, 2H); 7.38 (dd, 1H); 7.74 (d, 1H); 8.50 (d, 1H); 8.52 (s, 1H); 8.63 (s, 1H) 13C-NMR (DMSO): 38.52; 123.4; 129.7; 137.1; 141.7; 142.6; 148.1; 150.3; 161.8; 170.7

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Neuropharma, S.A.; EP1849785; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-66-0,2,5-Dimethylthiazole,as a common compound, the synthetic route is as follows.

To a solution of 2, 5-dimethylthiazole (0.730 g, 5.10 mmol) in benzene (80 mL). add N-bromosuccinimide (0.908 g, 5.10 mmol) and a catalytic amount of benzoyl peroxide. Heat the solution at reflux for 2 hours and stir overnight at room temperature. Cool the mixture, dilute with diethyl ether, wash with saturated NA2*S03 (75 mL), followed by saturated sodium hydrogencarbonate (75 mL), dry (NA2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 100% diethyl ether to afford 390 mg of the title compound. IN NMR (CDCL3) 67. 39 (s, 1H), 4.70 (s, 2H), 2.48 (s, 3H)., 4175-66-0

The synthetic route of 4175-66-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

40283-46-3, 2-Aminothiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 14: 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic acid BocHN [0111] A mixture of 2-aminothiazole-5-carboxylic acid (2.2 kg, 15.33 mol), aqueous 2 M NaOH (0.674 kg in 8.39 L of DI water), DI water (17.68 L), and THF (17.68 L) was cooled to about 0C. A solution of Boc-anhydride (4.02 kg, 1.20 equiv) in THF (2.21 L) was added to the mixture while maintaining an internal temperature below 5C. When the addition was complete, the reaction mixture was warmed to an internal temperature of 25C and was stirred for 24 hours. The reaction mixture was cooled to about 0C and diluted with DI water (22.1 L). While maintaining an internal temperature below 5C, the pH of the mixture was adjusted to 4.9 by slowly adding acetic acid (5.30 L). After 1 hour a precipitate formed, which was collected by filtration, and rinsed successively with DI water (6.63 L) and MTBE (4.42 L). The filter cake was held under nitrogen for 1 hour and then dried under reduced pressure at 25C to afford the title compound (5.14 kg).

40283-46-3, The synthetic route of 40283-46-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATTHEWS, Christopher; O’BRYAN, Colin; PROVENCAL, David Paul; WO2012/51450; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica