4175-76-2,4175-76-2, 2,4-Dichlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2,4-Dichlorothiazole (10 g, 64.9 mmol) was dissolved in acetic acid (50.0 ml) and heated to 60 C. Bromine (15.05 ml, 292 mmol) was added dropwise and the reaction mixture then stirred at 90 C. for 5.5 hours. The reaction was cooled to room temperature and made basic by slow addition of solid sodium carbonate, then diluted with water (100 mL) and extracted with Et2O (3*150 ml). The combined organic extracts were washed with sat.aq. sodium thiosulfate (50 ml) dried over sodium sulfate evaporated under reduced pressure to afford the title compound as a pale yellow oil. LC-MS Rt 1.43 min [M+H]+ 275.9/277.9/279.9/281.9 (Method 2minLowpHv03)
The synthetic route of 4175-76-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; BLOOMFIELD, Graham Charles; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPERD, Jon; WRIGHT, Paul; US2014/171412; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica