14542-16-6, 4-Methylthiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 4-methylthiazole-2-carboxylic acid (50.0 mg, 0.349 mmol) and CDI (84.9 mg,0.524 mmol) in THF (5.0 mL) was stirred at room temperature for 1 h, 2-amino-6-methylpyridine (37.7 mg, 0.349 mmol) was added. The mixture was stirred at room temperature for 2 h. The subsequent mixture was concentrated under reduced pressure and extracted with H2O/ethyl acetate. The combined organic layer was dried over Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 10:1) to afford the title compound 6ae (55 mg, 57 %) as white solid; 1H-NMR (400MHz, CDCl3) delta 9.61(s, 1H), 8.12 (d, J = 8 Hz, 1H), 7.63(t, J = 8 Hz, 1H), 7.18 (d, J = 0.8, 1H), 6.93 (d, J = 7.2, 1H), 2.49 (d, J = 1.2, 1H). 13C-NMR (100MHz, CDCl3) delta 162.0, 157.7, 157.2, 154.4, 150.0, 138.7,120.4, 119.6, 110.9, 24.1, 17.0. LC/MS (ESI-) 234.1 (M+H)+., 14542-16-6
The synthetic route of 14542-16-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica