20949-84-2, 4-Formyl-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation 51 6-FLUORO-2-[2-(2-METHYL-THIAZOL-4-YL)-VINYL]-3-(2-METHYL-PHENYL)-3H-QUINAZOLIN-4-ONE Anhydrous zinc chloride (0.136 g, 1.0 mmol) was fused with a nitrogen purge in a round bottom flask with an open flame. The reaction vessel was allowed to return to ambient temperature, then dioxane (10 mL) was added. To this mixture was added 6-fluoro-2-methyl-3-(2-methyl-phenyl)-3H-quinazolin-4-one (0.1 34 g, 0.5 mmol), acetic anhydride (0.141 mL, 1.5 mmol), and 2-methylthiazole-4-carboxaldehyde (0.191 g, 1.5 mmol). The reaction was refluxed 3.5 hours, at which time the reaction was allowed to cool to ambient temperature. Once the reaction had cooled to ambient temperature it was diluted with water. The resulting mixture was repeatedly extracted with chloroform. The chloroform extracts were combined and the resulting chloroform layer was washed with water and brine, dried over sodium sulfate and concentrated to leave a dark residue. This residue was triturated with ether, filtered and dried to afford 0.04 g (21%) of 6-fluoro-2-[2-(2-methyl-thiazol-4-yl)-vinyl]-3-(2-methyl-phenyl)-3H-quinazolin-4-one as a tan solid. Melting point: 211-212 C.; NMR delta 7.91 (dd, J=3, 8.3 Hz, 1 H), 7.87 (d, J=15 Hz, 1 H), 7.75 (dd, J=5, 9 Hz, 1 H), 7.49 (dt, J=3, 9 Hz, 1 H), 7.42 (sym m, 3 H), 6.61 (d, J=15 Hz, 1 H), 2.60 (s, 3 H), 2.09 (s, 3 H)., 20949-84-2
20949-84-2 4-Formyl-2-methylthiazole 2763191, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Pfizer Inc.; US6306864; (2001); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica