With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.117043-86-4,4-(Aminomethyl)thiazole Hydrochloride,as a common compound, the synthetic route is as follows.
To a solution of thiazol-4-ylmethanamine hydrochloride (100 mg, 0.664 mmol) in acetonitrile (3 mL), potassium carbonate (229 mg, 1.66 mmol) and DMF (2 mL) were added. After the mixture was cooled to a temperature between -10 C. and -15 C., ethyl 2-bromoacetate (73 muL, 0.66 mmol) diluted with acetonitrile (1 mL) was added dropwise thereto. The temperature was gradually raised to room temperature, and the mixture was stirred overnight. Insoluble matters were separated by filtration, and the filtrate was concentrated under reduced pressure., 117043-86-4
As the paragraph descriping shows that 117043-86-4 is playing an increasingly important role.
Reference£º
Patent; Ajinomoto Co., Inc.; MATSUMOTO, Kayo; MIYANAGA, Wataru; DOHI, Mizuki; NAKAGAWA, Tadakiyo; KOBAYASHI, Kaori; TAKESHITA, Sen; (67 pag.)US2016/46592; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica