494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 12: 1,1-dimethylethyl[4-(bromomethyl)-1,3-thiazol-2-yl]carbamate Intermediate 4 (1,1-dimethylethyl[4-(hydroxymethyl)-1,3-thiazol-2-yl]carbamate, 410 mg, 1.78 mmol) was dissolved in 5 mL of anhydrous DCM. Phosphorous tribromide (ALDRICH, 530 mg, 1.958 mmol) was added at 0 C. Reaction mixture was stirred at room temperature overnight. Reaction was diluted with 5 mL of water and extracted with DCM (3*5 mL). Organic layer was dried over MgSO4 (anh), filtered and concentrated to give the title compound (300 mg, 1.02 mmol, 58% yield). 1H NMR (400 MHz, DMSO-d6) delta ppm: 11.56 (br s, 1H), 7.23 (s, 1H), 4.60 (s, 2H), 1.48 (s, 9H).
494769-44-7, The synthetic route of 494769-44-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Mallo-Rubio, Araceli; US2013/203802; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica