Month: November 2020

10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of aluminum lithium hydride (671 mg) in THF (20 ml), a solution of 2-thiazolecarboxyaldehyde (2.0 g) in THF (20 ml) was added dropwise at 0C under nitrogen atmosphere. After finishing the dropping, water (0.7 ml), 15% aqueous solution of sodium hydroxide (0.7 ml), and water (2.1 ml) were sequentially added to the mixture at 0C, and the mixture was stirred for 2.5 hours at room temperature. The mixture was dried over magnesium sulfate, and the insolubles were filtered off. The solvent was distilled off under reduced pressure, to give 2-hydroxymethylthiazole (1.0 g) as brown oil. 1H-NMR (200 MHz, CDCl3) delta 4.98 (2H, s), 7.33 (1H, d, J = 3.4 Hz), 7.75 (1H, d, J = 3.0 Hz), 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; EP1422228; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-bromothiazole-5-carbonitrile (259 mg, 1.37 mmol), 6-phenylpiperidin-2-one (200 mg, 1.14 mmol), cesium carbonate (558 mg, 1.71 mmol), XantPhos (52.8 mg, 0.091 mmol),and Pd(Ph3P)4 (132 mg, 0.114 mmol) in dioxane (3 mL) in a sealed tube was heated at 125 C for 18 h under N2. The reaction mixture was cooled to room temperature and partitioned between water (20 mL) and ethyl acetate (30 mL x 2). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by reverse-phase prep-HPLC (preparative HPLC on a GILSON 281 instrument fitted with Waters XSELECT C18 l5Ox3Ommx5um using water and acetonitrile as the eluents, mobile phase A:water, mobile phase B: acetonitrile (containing: 0.1%TFA-ACN), gradient: 38-68%, 0-10 mm; 100% B, 10.5-12.5 mm; 5% B, 13-15 mm) to give 2-(2-oxo-6-phenylpiperidin-1-yl)thiazole-5- carbonitrile as a solid. ESI-MS m/z [M+Hf?: 284.0.

440100-94-7, 440100-94-7 2-Bromothiazole-5-carbonitrile 17860952, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; WALJI, Abbas; BERGER, Richard; STUMP, Craig, A.; SCHLEGEL, Kelly Ann, S.; MULHEARN, James, J.; GRESHOCK, Thomas, J.; GINNETTI, Anthony, T.; WANG, Deping; STACHEL, Shawn, J.; FRALEY, Mark, E.; (87 pag.)WO2017/222950; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-48-8,2-Bromo-5-nitrothiazole,as a common compound, the synthetic route is as follows.

Synthesis of 1-(5-nitrothiazol-2-yl)piperazine 1-(5-nitrothiazol-2-yl)piperazine was obtained by reaction of 2-bromo-5-nitrothiazole with piperazine under the conditions described above Precursor BBB24., 3034-48-8

The synthetic route of 3034-48-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gruenenthal GmbH; US2007/112011; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78502-71-3,78502-71-3, Ethyl 2-(bromomethyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation Example 26; 3-Phenylpropan-1-amine (11.33 g) and potassium carbonate (11.58 g) were added to acetonitrile (300 mL), and MeOH and a solution of ethyl 2-(bromomethyl)-1,3-thiazole-4-carboxylate (11.64 g) in acetonitrile (30 mL) in an ice bath were slowly added dropwise thereto, followed by stirring at room temperature for about 1 hour. To the reaction mixture was added an appropriate amount of ice water, followed by extraction with ethyl acetate several times. The organic layer was washed with brine and dried over MgSO4, and then the solvent was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate_hexane=3:1 to 5:1) to prepare ethyl 2-{[(3-phenylpropyl)amino]methyl}-1,3-thiazole-4-carboxylate (13.17 g).

The synthetic route of 78502-71-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Astellas Pharma Inc.; US2012/184521; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

78364-55-3, General procedure: 6-Fluoro-2-(2-(5-(un)substituted-2-oxoindolin-3-ylidene)hydrazino)benzothiazoles 5a-c. General Procedure C. A mixture of compound 2 (0.183 g, 0.001 mol), the appropriate isatin (0.001 mol) and glacial acetic acid (0.1 mL) in ethanol (20 mL) was heated at reflux temperature for 4-6 h. The precipitated yellow to orange solid was collected by filtration, washed with ethanol, dried and crystallized from methanol to yield compounds 5a-c.

As the paragraph descriping shows that 78364-55-3 is playing an increasingly important role.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-formaldehyde thiazole (113 mg, 1mmol) dissolved in 2 ml methanol, by adding 2-hydroxypropanedinitrile acetic acid solution (0.4 ml, 5mol/L), then rapidly added to 4-dimethyl aminopyridine (12 mg), 50 ¡ãC stirring under 40 minutes. After concentrating the reaction solution through the column chromatography separation to obtain 4 – (hydroxy-a)-thiazole acetic acid methyl ester (144 mg, 83percent)., 3364-80-5

As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.

Reference£º
Patent; Shanghai Syn-The-All Pharmaceutical Co. Ltd.; Zhang, ZhiLiu; Lin, XiaoJuan; Yu, Haiyu; Wu, Chengde; Ma, RuJian; Chen, ShuHui; (8 pag.)CN103086881; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-66-0,2,5-Dimethylthiazole,as a common compound, the synthetic route is as follows.

To a solution of 2, 5-dimethylthiazole (0.730 g, 5.10 mmol) in benzene (80 mL). add N-bromosuccinimide (0.908 g, 5.10 mmol) and a catalytic amount of benzoyl peroxide. Heat the solution at reflux for 2 hours and stir overnight at room temperature. Cool the mixture, dilute with diethyl ether, wash with saturated NA2*S03 (75 mL), followed by saturated sodium hydrogencarbonate (75 mL), dry (NA2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 100% diethyl ether to afford 390 mg of the title compound. IN NMR (CDCL3) 67. 39 (s, 1H), 4.70 (s, 2H), 2.48 (s, 3H).

4175-66-0, As the paragraph descriping shows that 4175-66-0 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-24-5,2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide,as a common compound, the synthetic route is as follows.

Add 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide A (4mmol, 1071mg), compound N1 (4mmol, 601mg) to the flask, add no 150ml of water toluene was installed on the water separator device, and the reaction was heated and refluxed for 24h. After the reaction was completed, toluene was distilled off under reduced pressure to obtain crude intermediate O1., 302964-24-5

302964-24-5 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 21911644, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Medical University; Zhao Jinwu; Xu Jingxiu; Zuo Changqing; (12 pag.)CN111039890; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

To a stirred solution of Compound J (5.6 g, 40 mmol) and CuBr (8.5 g, 60 mmol) in CH3CN (100 mL) was added dropwise t-BuONO (6.2 g, 7.2 mL, 60 mmol) at 0 ¡ãC. Then the reaction mixture was warmed to room temperature and further stirred for additional 30 mins. After that, the precipitate was filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (eluent: 100percent petroleum ether) to afford the desired product K (3.5 g, 43 percent) as a light yellow oil containing small amount of petroleum ether. 1H NMR (400 MHz, CDC13): delta 6.77 (s, 1H), 2.00-1.95 (m, 1H), 0.94-0.85 (m, 4H)., 324579-90-0

The synthetic route of 324579-90-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GUO, Lei; HU, Taishan; HU, Yimin; KOCER, Buelent; LIN, Xianfeng; LIU, Haixia; MAYWEG, Alexander V.; QIU, Zongxing; SHEN, Hong; TANG, Guozhi; WANG, Lisha; WU, Guolong; YAN, Shixiang; ZHANG, Weixing; ZHOU, Mingwei; ZHU, Wei; WO2014/37480; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-01-2,Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

b) Preparation of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate [Compound of formula IV1.350.0gm of Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate, [Compound of formula III] 332. Ogm of potassium carbonate and 330.0gm of isobutyl bromide were added to 1.751tr of DMF. Reaction mixture was heated to 90 +/- 3C and stirred for 4 hr. Reaction mixture was cooled to 25C and slowly added 10.50 ltr of water. Slurry of the product formed was stirred for 2.0hr, filtered, washed and dried under vacuum to give 389 gm of titled compound.Analytical Data- ¡¤ ^NMR (CDC13, 400 MHz) : delta 1.079-1.101 (doublet, 6H); delta 1.366-1.413 (triplet,3H); delta 2.185-2.230 (multiplet, 1H); delta 2.769 (singlet, 3H); delta 3.914-3.935 (doublet, 2H); delta 4.316-4.387 (quartet, 2H); delta 7.045-7.074 (doublet, 1H); delta 8.188-8.225 (doublet of doublet, 1H); delta 8.353-8.361 (doublet, 1H).? Mass (m/e): 348.3

161798-01-2, The synthetic route of 161798-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica