Month: November 2020

1477-42-5, 4-Methylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The reaction carried out with 4-chloro-4-fluorobutyrophenone 7 (0.5ml, 3.04mmol) with imidazole 28 (0.21g, 3.04mmol) and K2CO3 (1g, 7.23mmol) in DMSO at 140C till the completion of reaction (TLC). After the completion of reaction, the workup was done with ethylacetate and water and then the organic layer was separated, dried over anhydrous Na2SO4 and evaporated under reduced pressure. The latter was purified by silica gel (60-120 mesh) column chromatography using ethylacetate: hexane (1:1) as eluent to give the title compound in 80% yield (0.51g), 1477-42-5

The synthetic route of 1477-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Singh, Kartikey; Sona, Chandan; Ojha, Vikash; Singh, Maninder; Mishra, Ankita; Kumar, Ajeet; Siddiqi, Mohammad Imran; Tripathi, Rama P.; Yadav, Prem N.; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 499 – 516;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101012-12-8,2-Chloro-1,3-thiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

2-Ch[oro-1,3-thiazo[e-4-carboxy[ic acid [CAS RN: 5198-87-8] (430 mg,2.55 mmo[, 1.0 eq) in 17 mL ethyl. acetate was treated with T3P solution [50 % in ethyl acetate] (3.80 mL, 6.37 mmol, 2.5 eq) and with acetohydrazide [CASRN: 1068-57-1] (189 mg, 2.55 mmol, 1.0 eq). The resulting solution was stirred at 80 C overnight. The reaction mixture was hydrolysed with ice-water and extracted with ethyl acetate (3x). The combined organic phases were washedwith brine. The phases were separated by the use of a Whatman filter. The volatile components of the resulting organic phase were removed in vacuo and the crude material contained 350 mg (50% yield of theory) of the title compound in 80% purity (UPLC area-%), which were used without further purification.UPLC-MS (Method 2): R = 0.90 mm; MS (EI0): m/z = 202 [M+H].1H-NMR (400 MHz, DMSO-d6): oe [ppm] = 2.41 (5, 3H), 8.71 (5, 1H).

101012-12-8, As the paragraph descriping shows that 101012-12-8 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29182-42-1,Ethyl 2-(benzo[d]thiazol-2-yl)acetate,as a common compound, the synthetic route is as follows.

Step A: tert-Butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate (49 mg, 0.16 mmol) and ethyl 2-(benzo[d]thiazol-2-yl)acetate (35 mg, 0.16 mmol) were combined with piperidine (10 muL, 0.1 mmol) and acetic acid (6 muL, 0.1 mmol) in EtOH (1 mL). The mixture was heated at reflux for 1 h. After cooling the mixture to room temperature, a precipitate formed. The solid was collected by vacuum filtration, washed with 1:1 EtOH:H2O (1 mL) and dried under vacuum to afford tert-butyl 4-(3-(benzo[d]thiazol-2-yl)-2-oxo-2H-chromen-7-yl)piperazine-1-carboxylate.

29182-42-1, 29182-42-1 Ethyl 2-(benzo[d]thiazol-2-yl)acetate 359796, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PTC Therapeutics, Inc.; F. Hoffmann-La Roche AG; Woll, Matthew G.; Chen, Guangming; Choi, Soongyu; Dakka, Amal; Huang, Song; Karp, Gary Mitchell; Lee, Chang-Sun; Li, Chunshi; Narasimhan, Jana; Naryshkin, Nikolai; Paushkin, Sergey; Qi, Hongyan; Turpoff, Anthony A.; Weetall, Marla L.; Welch, Ellen; Yang, Tianle; Zhang, Nanjing; Zhang, Xiaoyan; Zhao, Xin; Pinard, Emmanuel; Ratni, Hasane; (317 pag.)US9617268; (2017); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344-72-9,Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Step 2: 2-(1-piperidinyl)-4-trifluoromethylthiazole-5-carboxylic Acid (A-33) Compound A-33 was prepared by the general procedure for step 2 of intermediate A-31 using compound A-32 as starting material. 1H NMR (500 MHz, CDCl3) delta 3.56 (m, 4H), 1.73 (m, 6H); LCMS (ESI) [M+1]+ 281.2., 344-72-9

As the paragraph descriping shows that 344-72-9 is playing an increasingly important role.

Reference£º
Patent; Ting, Pauline C.; Aslanian, Robert; Caplen, Mary Ann; Cao, Jianhua; Chan, Tin-Yau; Kim, David; Kim, Hyunjin; Kim, Jae-Hun; Kuang, Rongze; Lee, Joe F.; Schwerdt, John; Wu, Heping; Zorn, Nicolas; US2011/224137; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6633-61-0,Methyl 2-aminothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,6633-61-0

General procedure: A solution of the selected heterocyclic starting material (1.00 mmol) in THF (10 mL) and a solutionof isopentyl nitrite (141 mg, 1.20 mmol) in THF (10 mL) were both pumped at a flow rate of 0.25 mLmin1 with a Vapourtech ?Easy MedChem V3? system, meeting at a PTFE T-piece and the outputflowing through a 10.0 mL coil reactor maintained at 120 C, giving a residence time of 20 min.The pressure of the system was maintained at 7 bar with a back-pressure regulator. For compoundswhere an isolated yield was reported: the output mixture was concentrated under reduced pressureto give an oil (or powder). The oil (or powder) was purified using column chromatography withvarious mixtures of ethyl acetate and hexane as the eluent, or by recrystallisation using methanol, togive isolated compounds that showed no impurities by NMR spectroscopy. For compounds where aconversion was reported (due to volatility of products), the output mixture was carefully concentratedunder a reduced pressure of 100 mbar for 10 min and the conversion was calculated by integration ofproduct peaks to a quantified internal standard (nitrobenzene).

As the paragraph descriping shows that 6633-61-0 is playing an increasingly important role.

Reference£º
Article; Roeder, Liesa; Nicholls, Alexander J.; Baxendale, Ian R.; Molecules; vol. 24; 10; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

777-12-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.777-12-8,6-(Trifluoromethyl)benzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

To a solution of 6-(trifluoromethyl)-2-aminobenzothiazole (218 mg, 1.0 mmol) in dichloromethane (20 mL) was added l-Ethyl-3-(3-Dimethylaminopropyl)carbodiimide (EDC) (191 mg, 1.0 mmol) and 1 -hydroxy- 1 ,2, 3 -benzotriazole (HOBt) (13.5 mg, 0.1 mmol). Then added 2-{5-[l-acetyl-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-lH-5-pyrazolyl]-2- methoxyphenoxy}aceticacid (3) (458 mg, 0.1 mmol) and the reaction mixture was stirred at a temperature of 25 ¡ãC for 24h and the reaction was monitored by TLC. Then to this water is added and extracted with dichloromethane. The solvent was evaporated under vacuum to afford the crude product. This was further purified by column chromatography using ethyl acetate and hexane as solvent system to obtain the pure product (lOi) (528 mg, 80percent yield). NMR (CDC13): 8 10,82 (br s, 1H), 8.11 (s, 1H), 7.88 (d, 1H, J = 7.9 Hz), 7.67-7.70 (m, 1H), 6.98-7.02 (dd, lH, J = 7.9, 1.6 Hz), 6.96 (s, 2H), 6.90-6.94 (m, 2H), 5.51-5.56 (dd, l H, J = 1 1.9, 3.9 Hz), 4.79 (s, 2H), 3.99 (s, 3H), 3.91 (s, 6H), 3.89 (s, 3H), 3.71-3.79 (dd, lH, J = 11.9, 17.5 Hz), 3.10-3.15 (dd, 1H, J= 17.5, 4.7 Hz), 2.43 (s, 3H); ESIMS:659 (M+l)+.

777-12-8 6-(Trifluoromethyl)benzo[d]thiazol-2-amine 2735955, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; AHMED, Kamal; REDDY, Adla, Malla; PAIDAKULA, Suresh; RAO, Neigapula, Sankara; SHETTI, Rajesh, V., C., R., N., C.; WO2012/104857; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of substituted o-phenyldiamine (1.0 equiv), thiazole-4-aldehyde or pyridine-2-aldehyde (1.0 equiv) with sodium pyrosulfite in DMF was stirred at 120¡ã C overnight. On completion of the reaction monitored by TLC, the solvent was evaporated and the residue was purified by silica gel chromatography by DCM/MeOH system to afford the final product. If necessary, the crudeproduct could be recrystallized in DCM or dichloroethane to afford pure sample., 3364-80-5

As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.

Reference£º
Article; Zhang, Chao; Zhong, Bo; Yang, Simin; Pan, Liangkun; Yu, Siwang; Li, Zhongjun; Li, Shuchun; Su, Bin; Meng, Xiangbao; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3774 – 3780;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

161797-99-5, Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2: Synthesis of Ethyl-2-(3-Formyl-4-HvdroxyphenvD-4-Methyl-5-Thiazole CarboxylateHexamethylene tetramine (134 g, 0.971 mol) was added to a solution of ethyl 2-(4- hydroxyphenyl)-4-methyl-5-thiazol carboxylate (100 g, 0.38 mol) in methanesulfonic acid (500 mL) slowly over a period of about 30 minutes. The reaction mixture was heated to about 75¡ãC and stirred for about 10 hours. After completion of reaction, the reaction mixture was cooled to about 30¡ãC and water was added to it. The reaction mixture was further cooled to about 0¡ãC and stirred for about 1 hour. The solid thus obtained was filtered, washed with water and dried to give the title compound. (Yield: 80 g, 72.3percent)

161797-99-5, 161797-99-5 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 135509402, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; CHATTERJEE, Pranab; NATH, Asok; SOKHI, Sarbjot Singh; PRASAD, Mohan; WO2012/14117; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 12: 1,1-dimethylethyl[4-(bromomethyl)-1,3-thiazol-2-yl]carbamate Intermediate 4 (1,1-dimethylethyl[4-(hydroxymethyl)-1,3-thiazol-2-yl]carbamate, 410 mg, 1.78 mmol) was dissolved in 5 mL of anhydrous DCM. Phosphorous tribromide (ALDRICH, 530 mg, 1.958 mmol) was added at 0 C. Reaction mixture was stirred at room temperature overnight. Reaction was diluted with 5 mL of water and extracted with DCM (3*5 mL). Organic layer was dried over MgSO4 (anh), filtered and concentrated to give the title compound (300 mg, 1.02 mmol, 58% yield). 1H NMR (400 MHz, DMSO-d6) delta ppm: 11.56 (br s, 1H), 7.23 (s, 1H), 4.60 (s, 2H), 1.48 (s, 9H).

494769-44-7, The synthetic route of 494769-44-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Mallo-Rubio, Araceli; US2013/203802; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 20Ethyl 2-[(3aS,6i?,7i?37ai?>6-{(li2)-l-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-7-(4-fluoro-2- methylphenvDhexahydropyrano f 3 ,4-cl pyrrol-2(3H)-yl] – 1 ,3 -thiazol e-5 -carboxylateA solution of (3aS,6i?57i?,7alambda)-6-{(li?)-l-[3,5- bis(trifluoromethyl)phenyl]ethoxy}-7-(4-fluoro-2-methylphenyI)octahydropyrano[3,4-c]pyrrole (PREP 7) (85.6 mg, 0.17mmol), N,N-diisopropylethylamine (0.035 mL, 0.20 mmol) and ethyl 2- brorno-l,3-thiazole-5-carboxylate (0.052 mL, 0.35 mmol) in 3 mL of 1 ,4-dioxane was heated at 106 0C for 18 h. Volatiles were removed and the crude was purified by reverse phase etaPLC to afford the title compound. MS: (MH)+ 647.

41731-83-3, 41731-83-3 Ethyl 2-bromothiazole-5-carboxylate 3614103, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK & CO., INC.; WO2007/75528; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica