Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Dash, Anadi C. and a compound is mentioned, 2103-99-3, 4-(4-Chlorophenyl)thiazol-2-amine, introducing its new discovery. 2103-99-3
The kinetics of hydrolysis of schiff bases, N-salicylidene-2-amino-(4-substituted phenyl)thiazoles have been investigated in 20percent ethanol-water at 30.0 +/- 0.5 deg C, pH = 4.05-5.90 and I = 0.05 mol dm-3.The reaction proceeds via uncatalysed and acid-catalysed paths.The pseude-first order rate constant of the acid-independent path is insensitive to the nature of the substituent in the aldehyd and amine moieties.The overall acid-catalysed rate constant is, however, sensitive to the nature of substituent.This is due to the variation of the protonation constant of theschiff bases.Hydration of the aldimine linkage is believed to be rate-determining in both acid-dependent and acid-independent paths.
The kinetics of hydrolysis of schiff bases, N-salicylidene-2-amino-(4-substituted phenyl)thiazoles have been investigated in 20percent ethanol-water at 30.0 +/- 0.5 deg C, pH = 4.05-5.90 and I = 0.05 mol dm-3.The reaction proceeds via uncatalysed and acid-catalysed paths.The pseude-first order rate constant of the acid-independent path is insensitive to the nature of the substituent in the aldehyd and amine moieties.The overall acid-catalysed rate constant is, however, sensitive to the nature of substituent.This is due to the variation of the protonation constant of theschiff bases.Hydration of the aldimine linkage is believed to be rate-determining in both acid-dependent and acid-independent paths.
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Reference£º
Thiazole | C3H10135NS – PubChem,
Thiazole | chemical compound | Britannica