In an article, published in an article, once mentioned the application of 767-68-0, Name is 4-Bromobenzothiazole,molecular formula is C7H4BrNS, is a conventional compound. this article was the specific content is as follows.Quality Control of: 4-Bromobenzothiazole
Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder responsive to inhibition of Aurora kinase A and/or B. Formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from hydrogen, hydroxy, C 1 – C 3 alkyl, fluoro(C 1 -C 3 )alkyl, hydroxy(C 1 -C 3 )alkyl, C 1 -C 3 alkoxy, fluoro(C 1 – C 3 )alkoxy, hydroxyC 1 -C 3 alkoxy, -N(R 6 J-R 7 , – AIk-N(R 6 )-R 7 , -0-AIk-N(R 6 )-R 7 , – C(=O)OH, carboxy(C 1 -C 3 )alkyl, or -C(=O)-NH-R 8 ; R 6 , R 7 ,R 8 and -AIk- are as defined herein; R is hydrogen or C 1 C 3 alkyl; one of A and B is hydrogen and the other is a group -Z-Ar; -Z- is -C(=O)-NH-, -NH-C(=O)-, -C(=O)-N(-CH 3 )-, or -N(-CH 3 )-C(=O)-; and Ar is aryl or heteroaryl, optionally substituted with one or more halogen atoms, C 1 -C 3 alkyl radicals or trifluoromethyl radicals; or a pharmaceutically acceptable salt, hydrate or solvate thereof.
Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder responsive to inhibition of Aurora kinase A and/or B. Formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from hydrogen, hydroxy, C 1 – C 3 alkyl, fluoro(C 1 -C 3 )alkyl, hydroxy(C 1 -C 3 )alkyl, C 1 -C 3 alkoxy, fluoro(C 1 – C 3 )alkoxy, hydroxyC 1 -C 3 alkoxy, -N(R 6 J-R 7 , – AIk-N(R 6 )-R 7 , -0-AIk-N(R 6 )-R 7 , – C(=O)OH, carboxy(C 1 -C 3 )alkyl, or -C(=O)-NH-R 8 ; R 6 , R 7 ,R 8 and -AIk- are as defined herein; R is hydrogen or C 1 C 3 alkyl; one of A and B is hydrogen and the other is a group -Z-Ar; -Z- is -C(=O)-NH-, -NH-C(=O)-, -C(=O)-N(-CH 3 )-, or -N(-CH 3 )-C(=O)-; and Ar is aryl or heteroaryl, optionally substituted with one or more halogen atoms, C 1 -C 3 alkyl radicals or trifluoromethyl radicals; or a pharmaceutically acceptable salt, hydrate or solvate thereof.
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Reference£º
Thiazole | C3H5220NS – PubChem,
Thiazole | chemical compound | Britannica