Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 566169-93-5, C14H12N2OS. A document type is Article, introducing its new discovery., Application In Synthesis of 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
In an effort toward the visualization of Beta-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of ABeta plaques, to DO3A-monoamide that is capable of forming stable, noncharged complexes with different trivalent metal ions including Gd3+ for MRI and 111In3+ for SPECT applications. Proton relaxivity measurements evidenced binding of Gd(DO3A-PiB) to the amyloid peptide ABeta1-40 and to human serum albumin, resulting in a two- and four-fold relaxivity increase, respectively. Ex vivo immunohistochemical studies showed that the DO3A-PiB complexes selectively target ABeta plaques on Alzheimer’s disease human brain tissue. Ex vivo biodistribution data obtained for the In-analogue pointed to a moderate blood brain barrier (BBB) penetration in adult male Swiss mice (without amyloid deposits) with 0.36% ID/g in the cortex at 2 min post injection.
In an effort toward the visualization of Beta-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of ABeta plaques, to DO3A-monoamide that is capable of forming stable, noncharged complexes with different trivalent metal ions including Gd3+ for MRI and 111In3+ for SPECT applications. Proton relaxivity measurements evidenced binding of Gd(DO3A-PiB) to the amyloid peptide ABeta1-40 and to human serum albumin, resulting in a two- and four-fold relaxivity increase, respectively. Ex vivo immunohistochemical studies showed that the DO3A-PiB complexes selectively target ABeta plaques on Alzheimer’s disease human brain tissue. Ex vivo biodistribution data obtained for the In-analogue pointed to a moderate blood brain barrier (BBB) penetration in adult male Swiss mice (without amyloid deposits) with 0.36% ID/g in the cortex at 2 min post injection.
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Reference£º
Thiazole | C3H467NS – PubChem,
Thiazole | chemical compound | Britannica