Reference of 27149-27-5. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 27149-27-5, Name is 2-(4-Bromophenyl)thiazole. In a document type is Article, introducing its new discovery.
Cross coupling protocols were applied for the synthesis of 3-(4-heteroaryl-phenyl)-8-oxabicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl esters. Stille conditions produced the corresponding products in reasonable yields. Samarium iodide reduction of the resulting coupling products produced the 2beta-carbomethoxy-3alpha-aryl-8-oxabicyclo[3.2.1]octane diastereoisomers as the major, and the 2beta-carbomethoxy-3beta-aryl-8- oxabicyclo[3.2.1]octane diastereoisomer as the minor products. Both diastereomers manifested inhibition of the dopamine (DAT) and serotonin (SERT) transporters, with some selectivity for SERT inhibition.
Cross coupling protocols were applied for the synthesis of 3-(4-heteroaryl-phenyl)-8-oxabicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl esters. Stille conditions produced the corresponding products in reasonable yields. Samarium iodide reduction of the resulting coupling products produced the 2beta-carbomethoxy-3alpha-aryl-8-oxabicyclo[3.2.1]octane diastereoisomers as the major, and the 2beta-carbomethoxy-3beta-aryl-8- oxabicyclo[3.2.1]octane diastereoisomer as the minor products. Both diastereomers manifested inhibition of the dopamine (DAT) and serotonin (SERT) transporters, with some selectivity for SERT inhibition.
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Reference£º
Thiazole | C3H577NS – PubChem,
Thiazole | chemical compound | Britannica