Month: February 2021

Related Products of 348-40-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article£¬once mentioned of 348-40-3

Novel N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)- carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects was done using various models of experimental epilepsy. Initial anticonvulsant activities of the compounds were investigated using intraperitoneal (i.p.) maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The quantitative assessment after oral administration in rats showed that the most active was 2-methyl-4-oxo-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylcarbamoyl) quinazoline-3(4H)-carbothioamide (SA 24) with ED50 values of 82.5 mumol/kg (MES) and 510.5 mumol/kg (scPTZ). This molecule was more potent than phenytoin and ethosuximide which were used as reference antiepileptic drugs. To explain the possible mechanism for anticonvulsant action, some of the selected active compounds were subjected to GABA (gamma-amino butyric acid) assay and AMPA ((S)-2-amino-3-(3-hydroxyl-5-methyl-4-isoxazolyl) propionic acid) induced seizure test.

Novel N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)- carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects was done using various models of experimental epilepsy. Initial anticonvulsant activities of the compounds were investigated using intraperitoneal (i.p.) maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The quantitative assessment after oral administration in rats showed that the most active was 2-methyl-4-oxo-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylcarbamoyl) quinazoline-3(4H)-carbothioamide (SA 24) with ED50 values of 82.5 mumol/kg (MES) and 510.5 mumol/kg (scPTZ). This molecule was more potent than phenytoin and ethosuximide which were used as reference antiepileptic drugs. To explain the possible mechanism for anticonvulsant action, some of the selected active compounds were subjected to GABA (gamma-amino butyric acid) assay and AMPA ((S)-2-amino-3-(3-hydroxyl-5-methyl-4-isoxazolyl) propionic acid) induced seizure test.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 348-40-3 is helpful to your research., Related Products of 348-40-3

Reference£º
Thiazole | C3H10450NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2516-40-7, Name is 2-Bromobenzothiazole, molecular formula is C7H4BrNS. In a Article£¬once mentioned of 2516-40-7, Recommanded Product: 2-Bromobenzothiazole

A series of Pd(II)-enaminone complexes, termed Pd(eao)2, have been synthesized and characterized. The investigation on the catalytic activities of these new Pd(II)-reagents has proved that the Pd(eao)2-1 possesses excellent catalytic activity for the Suzuki- Miyaura cross coupling reactions of aryl bromides/chlorides with aryl/vinyl boronic acids in the environmentally benign media of aqueous PEG400 at low loading (5 mol?). The superiority of this Pd(II)-reagent to those commercial Pd(II) and Pd(0) catalysts in catalyzing the reactions has been confirmed by parallel experiments. What’s more, Pd(eao)2-2 has been found as a practical catalyst for the homo-coupling reactions of aryl boronic acids.

A series of Pd(II)-enaminone complexes, termed Pd(eao)2, have been synthesized and characterized. The investigation on the catalytic activities of these new Pd(II)-reagents has proved that the Pd(eao)2-1 possesses excellent catalytic activity for the Suzuki- Miyaura cross coupling reactions of aryl bromides/chlorides with aryl/vinyl boronic acids in the environmentally benign media of aqueous PEG400 at low loading (5 mol?). The superiority of this Pd(II)-reagent to those commercial Pd(II) and Pd(0) catalysts in catalyzing the reactions has been confirmed by parallel experiments. What’s more, Pd(eao)2-2 has been found as a practical catalyst for the homo-coupling reactions of aryl boronic acids.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 2-Bromobenzothiazole, you can also check out more blogs about2516-40-7

Reference£º
Thiazole | C3H2745NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 10200-59-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 10200-59-6, Name is 2-Thiazolecarboxaldehyde, molecular formula is C4H3NOS. In a Article£¬once mentioned of 10200-59-6

Reductive alkylation of 3-amino-12-N-methylcytisine by aromatic aldehydes synthesized a series of secondary amines. The nootropic activity of the synthesized compounds was studied in vivo (mnestic and antihypoxic properties) and in vitro (antiradical properties and ability to affect transcription factor HIF-1 DNA-binding activity). The cytotoxicity of the synthesized compounds was assessed. The lead compound was identified.

Reductive alkylation of 3-amino-12-N-methylcytisine by aromatic aldehydes synthesized a series of secondary amines. The nootropic activity of the synthesized compounds was studied in vivo (mnestic and antihypoxic properties) and in vitro (antiradical properties and ability to affect transcription factor HIF-1 DNA-binding activity). The cytotoxicity of the synthesized compounds was assessed. The lead compound was identified.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10200-59-6 is helpful to your research., Application of 10200-59-6

Reference£º
Thiazole | C3H4270NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole,molecular formula is C14H11NS, is a conventional compound. this article was the specific content is as follows.SDS of cas: 16112-21-3

A new, convenient synthesis of 2-substituted benzimidazoles and benzothiazoles is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity and excellent yields are main advantages of this procedure. Georg Thieme Verlag Stuttgart.

A new, convenient synthesis of 2-substituted benzimidazoles and benzothiazoles is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity and excellent yields are main advantages of this procedure. Georg Thieme Verlag Stuttgart.

Do you like my blog? If you like, you can also browse other articles about this kind. SDS of cas: 16112-21-3. Thanks for taking the time to read the blog about 16112-21-3

Reference£º
Thiazole | C3H856NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine,molecular formula is C7H5FN2S, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 6-Fluorobenzo[d]thiazol-2-amine

New fluorinated 2-aryl-benzothiazoles, -benzoxazoles, and -chromen-4-ones have been synthesized and their activity against MCF-7 and MDA 468 breast cancer cell lines compared with the potent antitumor benzothiazole 5. Analogues such as 9a,b and 12a,d yielded submicromolar GI50 values in both cell lines; however, none of the new compounds approached 5 in terms of antitumor potency. For 5, binding to the aryl hydrocarbon receptor appeared to be necessary but not sufficient for growth inhibition.

New fluorinated 2-aryl-benzothiazoles, -benzoxazoles, and -chromen-4-ones have been synthesized and their activity against MCF-7 and MDA 468 breast cancer cell lines compared with the potent antitumor benzothiazole 5. Analogues such as 9a,b and 12a,d yielded submicromolar GI50 values in both cell lines; however, none of the new compounds approached 5 in terms of antitumor potency. For 5, binding to the aryl hydrocarbon receptor appeared to be necessary but not sufficient for growth inhibition.

Do you like my blog? If you like, you can also browse other articles about this kind. Recommanded Product: 6-Fluorobenzo[d]thiazol-2-amine. Thanks for taking the time to read the blog about 348-40-3

Reference£º
Thiazole | C3H10458NS – PubChem,
Thiazole | chemical compound | Britannica

16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 16112-21-3, Quality Control of: 2-(4-Methylphenyl)benzothiazole

An efficient one pot synthesis of 2-arylbenzothiazole derivatives through condensation of aldehydes and 2-aminothiophenol in the presence of catalytic amount of La(NO3)3¡¤6H2O under mild reaction conditions was developed. The key advantages of this protocol are short reaction time, high to excellent yields, simple work up, inexpensive catalyst and simple separation of pure product.

An efficient one pot synthesis of 2-arylbenzothiazole derivatives through condensation of aldehydes and 2-aminothiophenol in the presence of catalytic amount of La(NO3)3¡¤6H2O under mild reaction conditions was developed. The key advantages of this protocol are short reaction time, high to excellent yields, simple work up, inexpensive catalyst and simple separation of pure product.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 2-(4-Methylphenyl)benzothiazole. In my other articles, you can also check out more blogs about 16112-21-3

Reference£º
Thiazole | C3H775NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.38205-60-6, Name is 1-(2,4-Dimethylthiazol-5-yl)ethanone, molecular formula is C7H9NOS. In a Patent£¬once mentioned of 38205-60-6, Application In Synthesis of 1-(2,4-Dimethylthiazol-5-yl)ethanone

The present invention is related to a compound represented by formula (I) wherein R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like; X is ?N(R3)?, ?O?, or ?S?; Y is ?C(R4)?, or ?N?; Z is ?N(R7)?, ?O?, or ?S?; R2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: ?(CR2aR2b)n?R2c, wherein R2a is each independently a hydrogen atom, halogen, or the like; R2b is each independently a hydrogen atom, halogen, or the like; R2a and R2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like; two of R2a which are attached to the adjacent carbon atoms and/or two of R2b which are attached to the adjacent carbon atoms may be taken together to form a bond; R2c is substituted or unsubstituted aromatic carbocyclyl, or the like; n is an integer from 1 to 3; R3 and R7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R4 and R5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like; R6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

The present invention is related to a compound represented by formula (I) wherein R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like; X is ?N(R3)?, ?O?, or ?S?; Y is ?C(R4)?, or ?N?; Z is ?N(R7)?, ?O?, or ?S?; R2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: ?(CR2aR2b)n?R2c, wherein R2a is each independently a hydrogen atom, halogen, or the like; R2b is each independently a hydrogen atom, halogen, or the like; R2a and R2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like; two of R2a which are attached to the adjacent carbon atoms and/or two of R2b which are attached to the adjacent carbon atoms may be taken together to form a bond; R2c is substituted or unsubstituted aromatic carbocyclyl, or the like; n is an integer from 1 to 3; R3 and R7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R4 and R5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like; R6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 38205-60-6 is helpful to your research., Application In Synthesis of 1-(2,4-Dimethylthiazol-5-yl)ethanone

Reference£º
Thiazole | C3H168NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 19975-56-5. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 19975-56-5, Name is 2-(Methylthio)-4,5-dihydrothiazole. In a document type is Article, introducing its new discovery.

The efficient and environmentally friendly thiation of heterocycles using P2S5 under microwave irradiation in solvent free condition is described.

The efficient and environmentally friendly thiation of heterocycles using P2S5 under microwave irradiation in solvent free condition is described.

If you are interested in 19975-56-5, you can contact me at any time and look forward to more communication.Electric Literature of 19975-56-5

Reference£º
Thiazole | C3H985NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 10200-59-6, Name is 2-Thiazolecarboxaldehyde,molecular formula is C4H3NOS, is a conventional compound. this article was the specific content is as follows.Computed Properties of C4H3NOS

The invention relates to compounds of formula whereinR1 is a 5 or 6 membered heteroaryl group, containing 1 to 3 heteroatoms, selected from N, O or S, and which groups are optionally substituted by one or two substituents, which are lower alkyl, ?(CH2)nOH, halogen or lower alkoxy, and wherein the heteroaryl groups may be optionally linked to the pyrazole ring via an alkylene or alkenyl group, or isphenyl, optionally substituted by one or two substituents being lower alkyl, hydroxy-lower alkyl, halogen, hydroxy or lower alkoxy or is?O(CH2)n,phenyl, benzofuryl, indolyl or benzothiophenyl, or is?S-lower alkyl;R2 and R4 are independently from each other hydrogen, cyano or ?S(O)2-phenyl;R3 is hydrogen, halogen or isa 5 or 6 membered heteroaryl group, containing 1 to 3 heteroatoms, selected from N, O or S, and which groups are optionally substituted by one or two substituents, which are lower alkyl, ?(CH2)n-aryl, hydroxy, halogen, lower alkoxy, morpholinyl, amino, lower alkylamino or ?C(O)NR?2, and wherein R? is lower alkyl or hydrogen, or isphenyl, optionally substituted by one or two substituents being halogen, lower alkyl, lower alkoxy, amino, di-lower alkyl amino, CF3, ?OCF3, ?NHC(O)lower alkyl, cyano, ?C(O)-lower alkyl, ?C(O)O-lower alkyl, ?S-lower alkyl, ?S(O)2NH-phenyl, ?S(O)2-methylpiperazinyl; or is?NR?R?, wherein R? and R? are independently from each other hydrogen, ?(CH2)nphenyl, which phenyl ring is optionally substituted by halogen or lower alkoxy, ?CH(lower alkyl)-phenyl, indan-1-yl, 1,2,3,4-tetrahydro-naphthalen, or cycloalkyl; or is?O-phenyl, which phenyl ring is optionally substituted by halogen, lower alkyl or lower alkoxy, ?O-tetrahydronaphthalenyl or ?O?CH2-6-methyl-pyridin-2-yl; or is-benzo[1,3]dioxolyl, -1H-indol-5-yl, naphthyl, benzofuran-2-yl, 1,3,4,9-tetrahydro-b-carbolin-2-yl, piperidin-1-yl, pyrrolidin-1-yl, piperazin-4-yl-methyl or morpholinyl;R5 is ?NR2, wherein R may be the same or different and is hydrogen, lower alkyl, phenyl, benzyl, ?CO-lower alkyl, ?CO-lower alkoxy, -lower alkenyl, ?CO(CH2)n-phenyl or ?COO(CH2)n-phenyl, wherein the phenyl ring is optionally substituted by CF3, lower alkoxy, halogen or lower alkyl, ?CO(CH2)3-NHCO-lower alkoxy, ?(CH2)n-phenyl, wherein the phenyl ring is optionally substituted by lower alkoxy, CF3 or halogen, or is 4,5-dihydro-1H-imidazol-2-yl-benzoic acid, 1,4,5,6-tetrahydro-pyrimidin-2-yl-benzoic acid or 4,5,6,7-tetrahydro-1H-[1,3]diazepin-2-yl-benzoic acid;n is 0-4and their pharmaceutically acceptable salts

The invention relates to compounds of formula whereinR1 is a 5 or 6 membered heteroaryl group, containing 1 to 3 heteroatoms, selected from N, O or S, and which groups are optionally substituted by one or two substituents, which are lower alkyl, ?(CH2)nOH, halogen or lower alkoxy, and wherein the heteroaryl groups may be optionally linked to the pyrazole ring via an alkylene or alkenyl group, or isphenyl, optionally substituted by one or two substituents being lower alkyl, hydroxy-lower alkyl, halogen, hydroxy or lower alkoxy or is?O(CH2)n,phenyl, benzofuryl, indolyl or benzothiophenyl, or is?S-lower alkyl;R2 and R4 are independently from each other hydrogen, cyano or ?S(O)2-phenyl;R3 is hydrogen, halogen or isa 5 or 6 membered heteroaryl group, containing 1 to 3 heteroatoms, selected from N, O or S, and which groups are optionally substituted by one or two substituents, which are lower alkyl, ?(CH2)n-aryl, hydroxy, halogen, lower alkoxy, morpholinyl, amino, lower alkylamino or ?C(O)NR?2, and wherein R? is lower alkyl or hydrogen, or isphenyl, optionally substituted by one or two substituents being halogen, lower alkyl, lower alkoxy, amino, di-lower alkyl amino, CF3, ?OCF3, ?NHC(O)lower alkyl, cyano, ?C(O)-lower alkyl, ?C(O)O-lower alkyl, ?S-lower alkyl, ?S(O)2NH-phenyl, ?S(O)2-methylpiperazinyl; or is?NR?R?, wherein R? and R? are independently from each other hydrogen, ?(CH2)nphenyl, which phenyl ring is optionally substituted by halogen or lower alkoxy, ?CH(lower alkyl)-phenyl, indan-1-yl, 1,2,3,4-tetrahydro-naphthalen, or cycloalkyl; or is?O-phenyl, which phenyl ring is optionally substituted by halogen, lower alkyl or lower alkoxy, ?O-tetrahydronaphthalenyl or ?O?CH2-6-methyl-pyridin-2-yl; or is-benzo[1,3]dioxolyl, -1H-indol-5-yl, naphthyl, benzofuran-2-yl, 1,3,4,9-tetrahydro-b-carbolin-2-yl, piperidin-1-yl, pyrrolidin-1-yl, piperazin-4-yl-methyl or morpholinyl;R5 is ?NR2, wherein R may be the same or different and is hydrogen, lower alkyl, phenyl, benzyl, ?CO-lower alkyl, ?CO-lower alkoxy, -lower alkenyl, ?CO(CH2)n-phenyl or ?COO(CH2)n-phenyl, wherein the phenyl ring is optionally substituted by CF3, lower alkoxy, halogen or lower alkyl, ?CO(CH2)3-NHCO-lower alkoxy, ?(CH2)n-phenyl, wherein the phenyl ring is optionally substituted by lower alkoxy, CF3 or halogen, or is 4,5-dihydro-1H-imidazol-2-yl-benzoic acid, 1,4,5,6-tetrahydro-pyrimidin-2-yl-benzoic acid or 4,5,6,7-tetrahydro-1H-[1,3]diazepin-2-yl-benzoic acid;n is 0-4and their pharmaceutically acceptable salts

Do you like my blog? If you like, you can also browse other articles about this kind. Computed Properties of C4H3NOS. Thanks for taking the time to read the blog about 10200-59-6

Reference£º
Thiazole | C3H4207NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 2103-99-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 2103-99-3, C9H7ClN2S. A document type is Article, introducing its new discovery.

A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5-chlorothiophene-2-carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under ultrasonication. The structures of the synthesized compounds were characterized by spectral parameters and also tested for antioxidant activity. Among all the tested compounds, methoxy substituted oxazolyl thiophene carboxamide (8c) displayed promising antioxidant activity. Besides, the electron donating groups on the phenyl ring enhanced the antioxidant activity when compared with the electron withdrawing groups.

A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5-chlorothiophene-2-carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under ultrasonication. The structures of the synthesized compounds were characterized by spectral parameters and also tested for antioxidant activity. Among all the tested compounds, methoxy substituted oxazolyl thiophene carboxamide (8c) displayed promising antioxidant activity. Besides, the electron donating groups on the phenyl ring enhanced the antioxidant activity when compared with the electron withdrawing groups.

If you are hungry for even more, make sure to check my other article about 2103-99-3. Application of 2103-99-3

Reference£º
Thiazole | C3H10311NS – PubChem,
Thiazole | chemical compound | Britannica