The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.80945-86-4, Name is 6-Bromo-2-chlorobenzothiazole, molecular formula is C7H3BrClNS. In a Patent£¬once mentioned of 80945-86-4, Product Details of 80945-86-4
The present invention relates to an oxadiazole derivative of formula (I)1 or a pharmaceutically acceptable salt or N-oxide thereof: wherein, R1 represents a hydrogen atom, a C1-2 alkyl group or a C3-4 cycloalkyl-C1-2 alkyl group, both R2 and R3 represent a C1-2 alkyl group; Ra represents a hydrogen atom or a C1-2 alkyl group; Rb represents a hydrogen atom, a C1-2 alkyl group, a C3-4, cycloalkyl group, a carboxy group, a carbamoyl group or a -CF3 group; Rc represents a linear or branched C2.5 alkyl group substituted with one substituent selected from a hydroxy group, a triazolyl group and a -P(O)(OH)2 group; a -(CH2)(1-2)-C(O)OR” group; a -NR”R”” group; a -(CH2)(1-2NR”R”” group; a -(CH2)(1-2)-NHC(O)R”” group; a -(CH2)(2-4)NH-(CH2)(1-3)-NR”R”” group; or a -O-(CH2)(2-3)NR”R”” group, wherein: R” represents a hydrogen atom or a C1-2 alkyl group, R”” represents a hydrogen atom; a C5-6 cycloalkyl group substituted with a carboxy group; a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom and substituted with a carboxy(C1-2alkyl) group; or a C1-2 alkyl group optionally substituted by one or more substituents selected from halogen atoms, hydroxy groups, methyl groups, amino groups, carbamoyl groups and carboxy groups; or R” and R”” together with the nitrogen atom to which they are attached form (a) a 4 to 6 membered saturated or unsaturated heterocyclic group, which contains, as heteroatom, one N atom and, optionally, one further N atom and which heterocyclic group is substituted with one or more substituents selected from a halogen atom, a hydroxy group, a methyl group, an oxy group and a carboxy group, or (b) a 5 membered heteroaryl group which contains, as heteroatom, one N atom and, optionally, one or more further N atoms and which heteroaryl group is optionally substituted with one substituent selected from an amino group and a carboxy group.
The present invention relates to an oxadiazole derivative of formula (I)1 or a pharmaceutically acceptable salt or N-oxide thereof: wherein, R1 represents a hydrogen atom, a C1-2 alkyl group or a C3-4 cycloalkyl-C1-2 alkyl group, both R2 and R3 represent a C1-2 alkyl group; Ra represents a hydrogen atom or a C1-2 alkyl group; Rb represents a hydrogen atom, a C1-2 alkyl group, a C3-4, cycloalkyl group, a carboxy group, a carbamoyl group or a -CF3 group; Rc represents a linear or branched C2.5 alkyl group substituted with one substituent selected from a hydroxy group, a triazolyl group and a -P(O)(OH)2 group; a -(CH2)(1-2)-C(O)OR” group; a -NR”R”” group; a -(CH2)(1-2NR”R”” group; a -(CH2)(1-2)-NHC(O)R”” group; a -(CH2)(2-4)NH-(CH2)(1-3)-NR”R”” group; or a -O-(CH2)(2-3)NR”R”” group, wherein: R” represents a hydrogen atom or a C1-2 alkyl group, R”” represents a hydrogen atom; a C5-6 cycloalkyl group substituted with a carboxy group; a 5- to 6-membered saturated heterocyclic ring containing one nitrogen atom and substituted with a carboxy(C1-2alkyl) group; or a C1-2 alkyl group optionally substituted by one or more substituents selected from halogen atoms, hydroxy groups, methyl groups, amino groups, carbamoyl groups and carboxy groups; or R” and R”” together with the nitrogen atom to which they are attached form (a) a 4 to 6 membered saturated or unsaturated heterocyclic group, which contains, as heteroatom, one N atom and, optionally, one further N atom and which heterocyclic group is substituted with one or more substituents selected from a halogen atom, a hydroxy group, a methyl group, an oxy group and a carboxy group, or (b) a 5 membered heteroaryl group which contains, as heteroatom, one N atom and, optionally, one or more further N atoms and which heteroaryl group is optionally substituted with one substituent selected from an amino group and a carboxy group.
The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 80945-86-4 is helpful to your research., Product Details of 80945-86-4
Reference£º
Thiazole | C3H10868NS – PubChem,
Thiazole | chemical compound | Britannica