Application of 59937-01-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 59937-01-8, Name is Ethyl 2-phenylthiazole-4-carboxylate, molecular formula is C12H11NO2S. In a Article£¬once mentioned of 59937-01-8
Exploration of scope of an optimized one-pot sequential procedure for preparing of 2,4-di- and 2,4,5-tri-substituted thiazoles has been accomplished. The synthesis was performed by the initial formation of a beta-keto-thioester intermediate from nucleophilic substitution of alpha-bromoketones with thioacid potassium salts, followed by treatment with ammonium acetate and one equivalent of acetic acid in toluene to form imine intermediate eventually leading to cyclization yielding thiazoles. This procedure should be highlighted with a flexible way to control the substitution pattern around thiazole ring by choosing appropriately substituted alpha-bromoketones even containing acid labile functionality and thioacid potassium salts, and thus its applicability is very wide.
Exploration of scope of an optimized one-pot sequential procedure for preparing of 2,4-di- and 2,4,5-tri-substituted thiazoles has been accomplished. The synthesis was performed by the initial formation of a beta-keto-thioester intermediate from nucleophilic substitution of alpha-bromoketones with thioacid potassium salts, followed by treatment with ammonium acetate and one equivalent of acetic acid in toluene to form imine intermediate eventually leading to cyclization yielding thiazoles. This procedure should be highlighted with a flexible way to control the substitution pattern around thiazole ring by choosing appropriately substituted alpha-bromoketones even containing acid labile functionality and thioacid potassium salts, and thus its applicability is very wide.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 59937-01-8 is helpful to your research., Application of 59937-01-8
Reference£º
Thiazole | C3H8213NS – PubChem,
Thiazole | chemical compound | Britannica