Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 30616-38-7, C13H10N2OS. A document type is Article, introducing its new discovery., HPLC of Formula: C13H10N2OS
3-Substituted cyclobutanones 2 are prepared by alkene/dichloroketene cycloadditions and subsequent dehalogenation.Reduction with LiAlH(OtBu)3 furnishes cis-cyclobutanols 3 in 95-100percent selectivity.Mitsunobu inversion turned out to be the only practical method to get trans isomers 4 in high selectivity.A stereoselective cyclobutanol –> bromocyclobutane conversion could be achieved only by a modified Mitsunobu reaction.Cross coupling between zinc derivatives of bromocyclobutanes 9 and aromatic bromides is not stereoselective. – Key Words: – Dichloroketene / Stereoselective ketone reduction / Mitsunobu reaction / Cyclobutyl bromides / Cross-coupling reaction
3-Substituted cyclobutanones 2 are prepared by alkene/dichloroketene cycloadditions and subsequent dehalogenation.Reduction with LiAlH(OtBu)3 furnishes cis-cyclobutanols 3 in 95-100percent selectivity.Mitsunobu inversion turned out to be the only practical method to get trans isomers 4 in high selectivity.A stereoselective cyclobutanol –> bromocyclobutane conversion could be achieved only by a modified Mitsunobu reaction.Cross coupling between zinc derivatives of bromocyclobutanes 9 and aromatic bromides is not stereoselective. – Key Words: – Dichloroketene / Stereoselective ketone reduction / Mitsunobu reaction / Cyclobutyl bromides / Cross-coupling reaction
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Reference£º
Thiazole | C3H5073NS – PubChem,
Thiazole | chemical compound | Britannica