Application of 121-66-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 121-66-4, Name is 5-Nitrothiazol-2-amine, SMILES is NC1=NC=C([N+]([O-])=O)S1, belongs to thiazoles compound. In a article, author is Jacob, Jaismy, introduce new discover of the category.
Novel approach of multi-targeted thiazoles and thiazolidenes toward anti-inflammatory and anticancer therapy-dual inhibition of COX-2 and 5-LOX enzymes
It is well established that cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) play a vital role in the initiation and progression of inflammatory reactions. Hence, thiazole and thiazolidene-based pharmacophore molecules were synthesized to obtain dual COX-2 and 5-LOX inhibitory activity. The synthesis of target compounds has been achieved by a novel green strategy. In vitro COX-1, COX-2, and 5-LOX evaluation of these molecules have shown the potential for an improved anti-inflammatory profile. Most promising compound among the series (2-(diphenylamino)-4-(4-nitrophenyl)thiazol-5-yl)(naphthalen-1-yl)methanone 7h (IC50 = 0.07 +/- 0.02 mu M) showed equivalent COX-2 inhibitory potency as that of positive control etoricoxib (IC50 = 0.07 +/- 0.01 mu M) and an enhanced selectivity index of 115.14. Compound 7h exhibited 5-LOX IC50 of 0.29 +/- 0.09 mu M and reference drug zileuton showed IC50 of 0.15 +/- 0.05 mu M. In vivo studies of 7h including carrageenan-induced paw edema assay (63% inhibition of paw edema), antiulcer studies, biochemical assays, qRT-PCR analysis, and anticancer studies indicated that the present study has identified a good lead compound for the development of a potential anti-inflammatory drug having improved gastric safety profile. [GRAPHICS] .
Application of 121-66-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 121-66-4 is helpful to your research.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica