Chemistry, like all the natural sciences, Recommanded Product: 96-53-7, begins with the direct observation of nature¡ª in this case, of matter.96-53-7, Name is 4,5-Dihydrothiazole-2-thiol, SMILES is SC1=NCCS1, belongs to thiazoles compound. In a document, author is Yang, Guoyu, introduce the new discover.
The synthesis of coumarin thiazoles containing a trifluoromethyl group and their antifungal activities
A series of novel coumarin thiazoles containing trifluoromethyl group 3a-31 were prepared through a one-pot reaction using 3-(trifluoroacetyl)coumarin as a starting material in solvent-free conditions. Their structures were confirmed using IR, H-1 NMR, C-13 NMR, HRMS and X-ray single crystal diffraction, and their antifungal activity against Fusarium. moniliforme (F. moniliforme), Fusarium. graminearum (F. graminearum), and Curvularia. lunata (C. lunata) was evaluated. Among the synthesized compounds, compound 3f showed the highest inhibitor rate of 74% at 0.5 mg/mL against F. moniliforme, and compound 3g exhibited the highest inhibitor rates of 89% and 93.4% at 0.5 mg/mL against F. graminearum and C. lunata, respectively. The introduction of trifluoromethyl group greatly improved the antifungal activity of counterpart 3g compared to the compound 4. (C) 2020 Published by Elsevier B.V. on behalf of King Saud University.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 96-53-7. Recommanded Product: 96-53-7.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica