Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C4H6N2S, 7305-71-7, Name is 2-Amino-5-methylthiazole, molecular formula is C4H6N2S, belongs to thiazoles compound. In a document, author is Kutyashev, Igor B., introduce the new discover.
3-Nitro-2-phenyl-2-trifluoromethyl-2H-chromenes in reactions with azomethine ylides from isatins and (thia)proline: synthesis of spiro[chromeno(thia)pyrrolizidine-11,3′-oxindoles]
1,3-Dipolar cycloaddition of stabilized azomethine ylides generated in situ from isatins and proline to 3-nitro-2-phenyl-2-trifluoromethyl-2H-chromenes in i-PrOH proceeds stereoselectively at room temperature and leads to the formation of hexahydro-6H-spiro[chromeno[3,4-a]-pyrrolizine-11,3′-indolin]-2′-ones with the cis arrangement of the trifluoromethyl group and the nitro group. A similar reaction with the participation of thiaproline-based ylides at 50 degrees C leads to mixtures of diastereomeric tetrahydro-6H,9H-spiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazole-11,3′-indolin]-2′-ones with a predominance of the cis- or trans-isomer. The stereochemistry of the obtained products was confirmed by the NOESY experiment and X-ray structural analysis. GRAPHICS
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 7305-71-7. Formula: C4H6N2S.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica