Properties and Exciting Facts About 55981-09-4

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 55981-09-4. Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate55981-09-4, Name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, SMILES is CC(OC1=CC=CC=C1C(NC2=NC=C([N+]([O-])=O)S2)=O)=O, belongs to thiazoles compound. In a article, author is Yanik, Hulya, introduce new discover of the category.

Synthesis, cytotoxic activities and molecular modeling studies of some 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives

Quinones, especially 1,4-naphthoquinones, are one of the most significant and widely distributed phytochemical groups in nature. 1,4-Naphthoquinones and their synthetic derivatives are found to possess remarkable cytotoxic activities. In this study, a series of 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives were synthesized and their structures were verified with spectral analysis. In vitro cytotoxic activities of the synthesized compounds were evaluated by using MTT assay against MKN-45 (Human Gastric cancer), MDA-MB-231 (Human Breast cancer) and HeLa (Human Cervical cancer) cell lines. Among the synthesized compounds, 3d inhibited MDA-MB-cell proliferation with an IC50 value of 0.276 mu M. Compound 3a inhibited HeLa and MKN-45 cell proliferation with IC50 values of 0.336 mu M and 8.769 mu M, respectively. Compound 3b inhibited HELA cell proliferation with an IC50 value of 0.269 mu M. Molecular docking results suggest that the ligands may bind to the hDNA TopoII beta binding pocket and partially exert their effects. These results propose that 2-aminonaphtho[2,3-d]thiazole-4,9-dion core has important biological effects and further explorations are worthwhile. (C)2020 ACG Publication. All right reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 55981-09-4. Recommanded Product: 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate.

Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica