Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Formula: C3H3N3O2S121-66-4, Name is 5-Nitrothiazol-2-amine, SMILES is NC1=NC=C([N+]([O-])=O)S1, belongs to thiazoles compound. In a article, author is Nehra, Nidhi, introduce new discover of the category.
CuAAC Mediated Synthesis of 2-HBT Linked Bioactive 1,2,3-Triazole Hybrids: Investigations through Fluorescence, DNA Binding, Molecular Docking, ADME Predictions and DFT Study
A series of three different classes of benzothiazole linked 1,2,3-triazole hybrid molecules with varying alkyl spacers (ethyl, propyl, and butyl) between 2-hydroxyphenyl benzothiazoles and 1,2,3-triazoles are efficiently synthesized under CuAAC condition. All compounds are satisfactorily characterized by FTIR, H-1-NMR, C-13-NMR, ESI-MS data and structures of some compounds were finally supported by single-crystal X-ray diffraction data. Most of the synthesized compounds exhibited good to better DNA binding property (0.28×10(5) M-1 to 2.91×10(5) M-1) and well drug-like properties. Some promising compounds showed good agreement to all experimental and theoretical computed properties (fluorescence study, DNA binding, molecular docking, DFT, and ADME Predictions).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 121-66-4. Formula: C3H3N3O2S.
Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica