38894-11-0, Name is 2-Hydrazono-3-methyl-2,3-dihydrobenzo[d]thiazole hydrochloride hydrate, molecular formula is C8H12ClN3OS, belongs to thiazoles compound, is a common compound. In a patnet, author is Radwan, Ahmed Sayed, once mentioned the new application about 38894-11-0, Category: thiazoles.
Synthesis, Antitumor Activity, and Docking Study of New Isatin-based Heterocycles
A sequence of new isatin-linked various heterocycles was prepared based on the condensation product of 3-(4-acetylphenylimino)indolin-2-one (1) with cyanoacetohydrazide. The produced isatin derivative 2 was used as the cornerstone to prepare plenty of isatin-based hybrids such as isatin-coumarin 4, isatin-thiophenes 5, 6, isatin-pyridines 7-9, and isatin-thiazoles 10-14. The structures were confirmed by spectroscopic and elemental analysis. Antitumor activity of the newly synthesized compounds was screened against three human cancer cell lines, namely, hepatocellular cancer (HepG2), colon cancer (HCT-116), and breast cancer (MCF-7). Compounds 6 and 13 were more effective; isatin-thiazolidine hybrid 13 showed the highest cytotoxic activity. The binding manner of the most active compounds 6 and 13 against 1HVY (thymidylate synthase, a protein that involves in DNA thinness) was illustrated using MOE software (2010.12).
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Reference:
Thiazole | C3H3NS – PubChem,
,Thiazole | chemical compound | Britannica