Application of 89336-46-9. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 89336-46-9, Name is 2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)acetic acid. In a document type is Article, introducing its new discovery.
A novel class of human beta3-adrenergic receptor agonists was designed in effort to improve selectivity and metabolic stability versus previous disclosed beta3-AR agonists. As observed, many of the beta3-AR agonists seem to need the acyclic ethanolamine core for agonist activity. We have synthesized derivatives that constrained this moiety by introduction of a pyrrolidine. This unique modification maintains human beta3 functional potency with improved selectivity versus ancillary targets and also eliminates the possibility of the same oxidative metabolites formed from cleavage of the N-C bond of the ethanolamine. Compound 39 exhibited excellent functional beta3 agonist potency across species with good pharmacokinetic properties in rat, dog, and rhesus monkeys. Early de-risking of this novel pyrrolidine core (44) via full AMES study supports further research into various new beta3-AR agonists containing the pyrrolidine moiety.
If you are interested in 89336-46-9, you can contact me at any time and look forward to more communication.Application of 89336-46-9
Reference£º
Thiazole | C3H368NS – PubChem,
Thiazole | chemical compound | Britannica