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The invention provides general formula (I) as shown in of sulfonamide-containing dihydothiazoles, ketone compounds and pharmaceutical compositions thereof and use. The compounds can be combined with domains of the bromodomain protein, thereby adjusting the signal path downstream of the, play a particular function, can be used for the treatment of the relevant domain protein bromodomain a variety of diseases. This kind of compound can be interference has Brd4 bromodomain domain of the combination of the acetylation of histone, and then downward oncogene c-myc and its related target transcription of the gene, so that it may be effective for the treatment of tumor drug. (by machine translation)
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Reference£º
Thiazole | C3H1332NS – PubChem,
Thiazole | chemical compound | Britannica