In an article, published in an article, once mentioned the application of 19952-47-7, Name is 2-Amino-4-chlorobenzothiazole,molecular formula is C7H5ClN2S, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 2-Amino-4-chlorobenzothiazole
Guanidinothiazolecarboxamides (GTCs) are a novel class of antitumor agents found to be systemically active against experimental pulmonary metastases of 3LL Lewis lung carcinoma.A series of substituted benzothiazole GTCs were found to produce enhancement of survival in this model by using 8 days of intraperitoneal dosing initiated 2 days after intravenous tumor challenge.Quantitative structure-activity relationships have been discovered in the GTC series with survival enhancement correlated to substituent parameters.Optimal correlations were found between the probit transform of the drug-induced increased lifespan (ILS) and field and ? parameters.Among the most effective analogues in this series was N-(5-fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide (19).
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Reference£º
Thiazole | C3H10033NS – PubChem,
Thiazole | chemical compound | Britannica