Related Products of 53137-27-2, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.53137-27-2, Name is 2,4-Dimethylthiazole-5-carboxylic acid, molecular formula is C6H7NO2S. In a patent, introducing its new discovery.
The development of an effective antitubercular agent is a challenge due to the complex nature of tuberculosis. Herein, we report the synthesis and evaluation of alpha-aminoacyl amides as antitubercular agents. The systematic medicinal chemistry approach led to identification of optimal substitutions required for the activity. Compound 11l was identified as antitubercular lead with drug like properties. Further, 11l selectively inhibited M. tuberculosis H37Rv with MIC value of 0.78 muM and was found to be non-toxic to CHO?K1 cells. The lead compound inhibited multidrug resistant and Pre-Extensively drug resistant strains of Mycobacterium at 2 mug/mL and 8 mug/mL respectively.
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Reference£º
Thiazole | C3H1664NS – PubChem,
Thiazole | chemical compound | Britannica