Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2289-75-0, Name is 4,5-Dimethylthiazol-2-amine, Product Details of 2289-75-0.
Synthesis and aldose reductase inhibitory activities of novel N-nitromethylsulfonanilide derivatives
A novel series of 14 N-nitromethylsulfonanilide derivatives were synthesized and evaluated for their ability to inhibit recombinant aldose reductase. Computational docking simulations provided a good explanation for the observed structure-activity relationships. Kinetic analysis of (2-fluoro-5-methyl-N-methyl)-N-nitromethylsulfonanilide, 11, one of the most potent compounds in this series with an IC50=0.35muM, showed uncompetitive inhibition. Subsequent in vitro culture studies of rat lenses with 11 indicated that this series of aldose reductase inhibitors are effective in either preventing or retarding sugar cataract formation associated with diabetes. Copyright (C) 2000 Elsevier Science Ltd.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 2289-75-0. In my other articles, you can also check out more blogs about 2289-75-0
Reference：
Thiazole | C3H5034NS – PubChem,
Thiazole | chemical compound | Britannica