144060-99-1, Name is 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid, molecular formula is C11H8FNO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 144060-99-1, Application In Synthesis of 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents
The peroxisome proliferator activated receptors PPARalpha, PPARgamma, and PPARdelta are ligand-activated transcription factors that play a key role in lipid homeostasis. The fibrates raise circulating levels of high-density lipoprotein cholesterol and lower levels of triglycerides in part through their activity as PPARalpha agonists; however, the low potency and restricted selectivity of the fibrates may limit their efficacy, and it would be desirable to develop more potent and selective PPARalpha agonists. Modification of the selective PPARdelta agonist 1 (GW501516) so as to incorporate the 2-aryl-2-methylpropionic acid group of the fibrates led to a marked shift in potency and selectivity toward PPARalpha agonism. Optimization of the series gave 25a, which shows EC50 = 4 nM on PPARalpha and at least 500-fold selectivity versus PPARgamma and PPARgamma. Compound 25a (GW590735) has been progressed to clinical trials for the treatment of diseases of lipid imbalance.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid. In my other articles, you can also check out more blogs about 144060-99-1
Reference：
Thiazole | C3H579NS – PubChem,
Thiazole | chemical compound | Britannica