Synthetic Route of 3364-80-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 3364-80-5, Name is Thiazole-4-carboxaldehyde. In a document type is Article, introducing its new discovery.
Optimization of KDM6B (JMJD3) HTS hit 12 led to the identification of 3-((furan-2-ylmethyl)amino)pyridine-4-carboxylic acid 34 and 3-(((3-methylthiophen-2-yl)methyl)amino)pyridine-4-carboxylic acid 39 that are inhibitors of the KDM4 (JMJD2) family of histone lysine demethylases. Compounds 34 and 39 possess activity, IC50 ? 100 nM, in KDM4 family biochemical (RFMS) assays with ?50-fold selectivity against KDM6B and activity in a mechanistic KDM4C cell imaging assay (IC50 = 6-8 muM). Compounds 34 and 39 are also potent inhibitors of KDM5C (JARID1C) (RFMS IC50 = 100-125 nM).
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Reference：
Thiazole | C3H9308NS – PubChem,
Thiazole | chemical compound | Britannica