Application of 53266-94-7. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 53266-94-7, Name is Ethyl 2-(2-aminothiazol-4-yl)acetate. In a document type is Article, introducing its new discovery.
A series of novel influenza neuraminidase (NA) inhibitors based on thiazole core were synthesized and evaluated for their ability to inhibit NA of influenza A virus (H3N2). All compounds were synthesized in good yields starting from commercially available 2-amino-4-thiazole-acetic ester using a suitable synthetic strategy. These compounds showed moderate inhibitory activity against influenza A NA. The most potent compound of this series is compound 4d (IC50=3.43 muM), which is about 20-fold less potent than oseltamivir, and could be used to design novel influenza NA inhibitors that exhibit increased activity based on thiazole ring.
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Reference：
Thiazole | C3H10816NS – PubChem,
Thiazole | chemical compound | Britannica